17408-14-9 Usage
Description
2'-(Trifluoromethyl)acetophenone is a clear colorless to very slightly yellow liquid, which is an organic compound with the chemical formula C8H6F3OS. It is characterized by the presence of a trifluoromethyl group attached to an acetophenone moiety, which consists of a phenyl ring and an acetyl group. 2'-(Trifluoromethyl)acetophenone is known for its unique chemical properties and potential applications in various fields.
Uses
Used in Organic Synthesis:
2'-(Trifluoromethyl)acetophenone is used as a synthetic intermediate for the preparation of various organic compounds, particularly those containing trifluoromethyl groups. Its unique structure allows for versatile reactions and transformations, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2'-(Trifluoromethyl)acetophenone is used as a key intermediate in the synthesis of trifluoromethyl-containing drugs. The trifluoromethyl group is known to impart metabolic stability and lipophilicity to the molecules, which can enhance their bioavailability and pharmacological properties. As a result, this compound plays a crucial role in the development of new drugs with improved therapeutic profiles.
Used in Chemical Research:
2'-(Trifluoromethyl)acetophenone is also used as a research tool in the field of organic chemistry. It serves as a model compound for studying the reactivity and selectivity of trifluoromethyl-containing molecules, as well as the development of new synthetic methods and catalysts for trifluoromethylation reactions.
Used in Material Science:
In the field of material science, 2'-(Trifluoromethyl)acetophenone can be used as a precursor for the synthesis of trifluoromethylated polymers and materials. These materials may exhibit unique properties, such as enhanced thermal stability, chemical resistance, and non-linear optical properties, which can be useful in various high-tech applications, including electronics, sensors, and coatings.
Used in the Direct Substitution of Chlorine by CF3:
2'-(Trifluoromethyl)acetophenone has been used to investigate the use of in situ generated CuCF3 for the direct substitution of chlorine by CF3 in various aromatic substrates. This application demonstrates the potential of this compound in facilitating selective and efficient trifluoromethylation reactions, which are of great importance in the synthesis of biologically active molecules and advanced materials.
Check Digit Verification of cas no
The CAS Registry Mumber 17408-14-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,4,0 and 8 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 17408-14:
(7*1)+(6*7)+(5*4)+(4*0)+(3*8)+(2*1)+(1*4)=99
99 % 10 = 9
So 17408-14-9 is a valid CAS Registry Number.
17408-14-9Relevant articles and documents
Copper-mediated trifluoromethylation using phenyl trifluoromethyl sulfoxide
Li, Xinjin,Zhao, Jingwei,Zhang, Liang,Hu, Mingyou,Wang, Limin,Hu, Jinbo
, p. 298 - 301 (2015)
A new method for the generation of trifluoromethylcopper ( CuCF3 ) species from readily available phenyl trifluoromethyl sulfoxide has been developed. The CuCF3 reagent can be applied in efficient trifluoromethylations of aryl iodides and activated aryl bromides in the absence of additional ligands. Furthermore, the CuCF3 species can also undergo oxidative cross-coupling with terminal alkynes and arylboronic acids.
One-Pot Chemoenzymatic Conversion of Alkynes to Chiral Amines
Mathew, Sam,Renn, Dominik,Rueping, Magnus,Sagadevan, Arunachalam
, p. 12565 - 12569 (2021/10/21)
A one-pot chemoenzymatic sequential cascade for the synthesis of chiral amines from alkynes was developed. In this integrated approach, just ppm amounts of gold catalysts enabled the conversion of alkynes to ketones (>99%) after which a transaminase was used to catalyze the production of biologically valuable chiral amines in a good yield (up to 99%) and enantiomeric excess (>99%). A preparative scale synthesis of (S)-methylbenzylamine and (S)-4-methoxy-methylbenzylamine from its alkyne form gave a yield of 59 and 92%, respectively, withee> 99%.
Efficient Palladium(0) supported on reduced graphene oxide for selective oxidation of olefins using graphene oxide as a ‘solid weak acid’
Gao, Xi,Zhou, Jianhao,Peng, Xinhua
, p. 73 - 78 (2019/02/06)
Selective oxidation of olefin derivatives to ketones has made innovative development over palladium(0) supported on reduced graphene oxide. Compared to traditional Wacker oxidation, the novel method offers an economical and environment-friendly option by using graphene oxide (GO) as a ‘solid weak acid’ instead of classical homogeneous catalysts like H2SO4 and CF3COOH. X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscope and transmission electron microscopy images of Pd0/RGO showed that the nanoscaled Pd particles generated at the flake structure of reduced graphene oxide. Under optimized condition, up to 44 kinds of ketones with different structures can be prepared with excellent yields.
