174221-82-0

Basic information

• Product Name: 5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil
• Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil
• CAS NO: 174221-82-0
• Molecular Weight: 672.949
• Mol File: 174221-82-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil(174221-82-0)
• EPA Substance Registry System: 5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxy-1-(β-D-ribofuranosyl)uracil(174221-82-0)

Safety Data

• Hazardous Substances Data: 174221-82-0(Hazardous Substances Data)

Upstream product

• 58-96-8 uridine 
• 3736-77-4 2,2'-Anhydrouridine 
• 545-06-2 trichloroacetonitrile 
• 173170-12-2 2,2'-O-anhydro-1-<5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl>uracil 

Downstream Products

• 174221-92-2 N⁴-benzoyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine 
• 174221-90-0 N-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2-oxo-4-[1,2,4]triazol-1-yl-2H-pyrimidin-1-yl)-4-trimethylsilanyloxy-tetrahydro-furan-3-yl]-2,2,2-trifluoro-acetamide 
• 174221-91-1 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine 
• 1053244-49-7 N-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-2,2,2-trifluoro-acetamide 
• 174221-89-7 N-[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-trimethylsilanyloxy-tetrahydro-furan-3-yl]-2,2,2-trifluoro-acetamide 
• 118849-17-5 5'-O-(4,4'-dimethoxytrityl)-2'-(trifluoroacetylamido)-2'-deoxyuridine 
• 174221-88-6 5'-O-(4,4'-dimethoxytrityl)-2'-trifluoroacetamido-2'-deoxycytidine 
• 174221-84-2 5'-O-(4,4'-dimethoxytrityl)-2'-N,3'-O-(2-(trichloromethyl)oxazolino)-2'-deoxycytidine 
• 174221-87-5 2'-amino-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine 
• 850452-76-5 1-{3-[bis(2-hydroxyethyl)amino]-5-[bis(4-methoxyphenyl)phenylmethoxymethyl]-4-hydroxytetrahydrofuran-2-yl}-3-methyl-1H-pyrimidine-2,4-dione 
• 850452-75-4 1-{3-amino-5-[bis(4-methoxyphenyl)phenylmethoxymethyl]-4-hydroxytetrahydrofuran-2-yl}-3-methyl-1H-pyrimidine-2,4-dione 
• 174221-86-4 5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine 
• 174221-83-1 1-{(3aR,4R,6R,6aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-trichloromethyl-3a,4,6,6a-tetrahydro-furo[3,4-d]oxazol-4-yl}-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one 

Relevant articles and documents

Novel nucleosides via intramolecular functionalization of 2,2'-anhydrouridine derivatives

The generation of novel ribonucleoside analogues derived from 2,2'-anhydrouridines by a 3'-hydroxyl directed intramolecular nucleophilic substitution of the 2'-position is described. The methodology allows for the efficient, regio- and stereoselective elaboration of the 2'-position, often under exceptionally mild reaction conditions.