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174221-86-4

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174221-86-4 Usage

General Description

Uridine, 2'-amino-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy- is a modified form of uridine that has been chemically altered to include an amino group at the 2' position and a bis(4-methoxyphenyl)phenylmethyl group at the 5' position. This modification is intended to enhance the stability and bioavailability of uridine. Uridine itself is a nucleoside that plays a key role in the synthesis of RNA and has also been studied for its potential cognitive and neuroprotective effects. The modification of uridine with an amino group and a phenylmethyl group may further enhance its biological activity and make it a more effective therapeutic agent for various health conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 174221-86-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,2,2 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 174221-86:
(8*1)+(7*7)+(6*4)+(5*2)+(4*2)+(3*1)+(2*8)+(1*6)=124
124 % 10 = 4
So 174221-86-4 is a valid CAS Registry Number.

174221-86-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(2R,3R,4S,5R)-3-amino-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names 5'-DMT-protected 2'-amino-2'-deoxyuridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:174221-86-4 SDS

174221-86-4Downstream Products

174221-86-4Relevant articles and documents

Synthesis of functionalised nucleosides for incorporation into nucleic acid-based serine protease mimics

Catry, Mieke A.,Madder, Annemieke

, p. 114 - 129 (2007)

The synthesis of nucleosides modified with an extra imidazole, carboxyl and hydroxyl group is described. These nucleosides can be incorporated into an oligonucleotide duplex, thus generating a novel type of serine protease mimic.

Efficient synthesis of 2′,3′-dideoxy-2′-amino-3′- thiouridine

Dai, Qing,Piccirilli, Joseph A.

, p. 2169 - 2172 (2007/10/03)

Metal ion rescue experiments provide a powerful approach to establish the presence and role of divalent metal ions in the biological function of RNA. The utility of this approach depends on the availability of suitable nucleoside analogues. To expand the

Method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement

-

, (2008/06/13)

A method for the preparation of 2'-modified nucleosides is provided. The method comprises a novel intramolecular nucleophilic displacement reaction. Included in the invention are novel 2'-modified pyrimidines and purines prepared according to the method of the invention, novel pyrimidines and purines bearing a 2',3' heterocyclic substituent and oligonucleotides containing said 2'-modified pyrimidines and purines. The 2'-modified nucleosides are useful as anti-viral and anti-neoplastic agents.

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