174221-86-4Relevant articles and documents
Synthesis of functionalised nucleosides for incorporation into nucleic acid-based serine protease mimics
Catry, Mieke A.,Madder, Annemieke
, p. 114 - 129 (2007)
The synthesis of nucleosides modified with an extra imidazole, carboxyl and hydroxyl group is described. These nucleosides can be incorporated into an oligonucleotide duplex, thus generating a novel type of serine protease mimic.
Efficient synthesis of 2′,3′-dideoxy-2′-amino-3′- thiouridine
Dai, Qing,Piccirilli, Joseph A.
, p. 2169 - 2172 (2007/10/03)
Metal ion rescue experiments provide a powerful approach to establish the presence and role of divalent metal ions in the biological function of RNA. The utility of this approach depends on the availability of suitable nucleoside analogues. To expand the
Method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement
-
, (2008/06/13)
A method for the preparation of 2'-modified nucleosides is provided. The method comprises a novel intramolecular nucleophilic displacement reaction. Included in the invention are novel 2'-modified pyrimidines and purines prepared according to the method of the invention, novel pyrimidines and purines bearing a 2',3' heterocyclic substituent and oligonucleotides containing said 2'-modified pyrimidines and purines. The 2'-modified nucleosides are useful as anti-viral and anti-neoplastic agents.