175021-13-3 Usage
Description
3-(chloromethyl)cyclobutanone is a cyclic ketone chemical compound with the molecular formula C5H7ClO. It features a chloromethyl group attached to a cyclobutanone ring, and is known for its colorless liquid form with a pungent odor. Due to its hazardous and potentially toxic nature, it requires careful handling and storage, adhering to proper safety protocols.
Uses
Used in Pharmaceutical Industry:
3-(chloromethyl)cyclobutanone serves as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows it to be a key component in creating a range of medicinal agents.
Used in Organic Synthesis:
As a reagent in organic synthesis, 3-(chloromethyl)cyclobutanone is utilized for its ability to participate in reactions such as nucleophilic substitution and addition reactions. This makes it a valuable tool in the creation of diverse organic molecules for different applications.
Check Digit Verification of cas no
The CAS Registry Mumber 175021-13-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,0,2 and 1 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 175021-13:
(8*1)+(7*7)+(6*5)+(5*0)+(4*2)+(3*1)+(2*1)+(1*3)=103
103 % 10 = 3
So 175021-13-3 is a valid CAS Registry Number.
175021-13-3Relevant articles and documents
Preparation of 2-Azabicyclo[21.1]hexane Hydrochloride
Liao, Haili,Li, Aimin,Chen, Xingsong,Liang, Kun,Shen, Yang,Liang, Qingfeng,Xu, Kewei,Shore, Daniel G. M.,Villemure, Elisia,Siu, Michael,Huestis, Malcolm P.
, p. 2251 - 2253 (2016)
A batchwise, multigram preparation of 2-azabicyclo-[2.1.1]hexane hydrochloride (1·HCl) was developed, delivering a total of 195 grams of material. The key synthetic step involves an intramolecular displacement of a primary alkyl chloride with a tert-butylsulfinamide to forge the [2.1.1]-bicyclic ring system.
Synthesis of 2,4-methanoproline analogues via an addition-Intramolecular substitution sequence
Rammeloo, Thomas,Stevens, Christian V.,De Kimpe, Norbert
, p. 6509 - 6513 (2007/10/03)
A new two-step synthetic approach toward 3-(chloromethyl)cyclobutanone is described and used in the synthesis of 2,4-methanoproline analogues. The key step consists of a reversible addition of hydrogen cyanide onto the imines 12 in 50-74% yield under conditions that allow ring closure. 2-Alkyl-2-azabicyclo [2.1.1]hexane-1-carbonitriles 19, synthesized in four steps, can also be converted to the corresponding amines.
