175021-15-5Relevant articles and documents
A new entry into 2-azabicyclo[2.1.1]hexanes via 3-(chloromethyl)cyclobutanone
Stevens,De Kimpe
, p. 2174 - 2178 (2007/10/03)
2-Azabicyclo[2.1.1]hexanes, which possess the skeleton of 2,4-methanoproline (a naturally occurring insect antifeedant), were synthesized by imination of the previously unknown 3-(chloromethyl)cyclobutanone and subsequent reductive cyclization. The precursor of the latter, 3-oxocyclobutane carboxylic acid, was prepared by two pathways in multigram quantities.