175274-01-8

Basic information

• Product Name: Furan, 2,5-dihydro-2-phenyl-, (2R)-
• CAS NO: 175274-01-8
• Molecular Formula: C10H10O
• Molecular Weight: 146.189
• Mol File: 175274-01-8.mol
• Article Data: 53

Chemical Properties

• CAS DataBase Reference: Furan, 2,5-dihydro-2-phenyl-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Furan, 2,5-dihydro-2-phenyl-, (2R)-(175274-01-8)
• EPA Substance Registry System: Furan, 2,5-dihydro-2-phenyl-, (2R)-(175274-01-8)

Safety Data

• Hazardous Substances Data: 175274-01-8(Hazardous Substances Data)

Upstream product

• 1191-99-7 2,3-dihydro-2H-furan 
• 17763-67-6 Phenyl triflate 
• 10147-11-2 propargyl benzene 
• 108-86-1 bromobenzene 
• 83564-70-9 4-phenylbuta-2,3-dien-1-ol 
• 1334430-38-4 diethyl (phenylethynyl)boronate 
• 536-74-3 phenylacetylene 
• 87751-69-7 rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene 
• 591-50-4 iodobenzene 
• 104516-09-8 1-phenylbuta-2,3-dien-1-ol 
• 108-95-2 phenol 
• 500-73-2 phenyl trifluoroacetate 
• 211310-54-2 Dimethyl-[2-((R)-(S)-2-phenyl-2,5-dihydro-furan-3-sulfinyl)-phenyl]-amine 

Relevant articles and documents

C1-Symmetric Binap Derivative Featuring Single Diferrocenylphosphino-Donor Moiety

A C1-symmetric chiral bisphosphine, FcPh-Binap (1), which possesses a single diferrocenylphosphino moiety together with a conventional Ph2P-substituent, was prepared in enantiomerically pure forms. Ligand 1 is sterically less demanding than Fc-Segphos (A)

Synthesis, Application and Kinetic Studies of Chiral Phosphite-Oxazoline Palladium Complexes as Active and Selective Catalysts in Intermolecular Heck Reactions

This study identifies new phosphite-oxazoline ligands that have been successfully applied in the palladium-catalyzed intermolecular asymmetric Heck reaction. The design of the new phosphite-oxazoline ligands derives from a previous successful generation of phosphine-oxazoline ligands, by replacing the phosphine group with several π-acceptor biaryl phosphite moieties. With these simple modifications, the new phosphite-based ligands, unlike previous phosphine-oxazoline, not only present a modular design with numerous potential phosphite groups available, but they are also air-stable solids, which can be made in the same number of synthetic steps as the phosphine analogues. The substitution of the phosphine by a biaryl phosphite group extended the range of substrates and triflates sources that can be coupled with regio-, enantioselectivities and activities comparable to the few best ones reported. In addition, the ligands that provided the best selectivities contained an isopropyl oxazoline moiety instead of the tert-butyl group found in the related phosphine-oxazoline ligands, which is made from a much more expensive precursor. In this paper we have also carried out kinetic studies and a Hammett plot analysis to determine the rate determining step of this system in the regime of interest. We suggest a likely explanation for the fast Heck reaction of the phosphite-oxazoline catalysts. (Figure presented.).

Synthesis, characterization and first application of chiral C2-symmetric bis(phosphinite)-Pd(II) complexes as catalysts in asymmetric intermolecular Heck reactions

A series of new chiral C2-symmetric bis(phosphinite) ligands and their palladium(II) complexes have been synthesized and for the first time used as catalysts in the palladium-catalysed asymmetric intermolecular Heck coupling reactions of 2,3-dihydrofuran with iodobenzene or aryl triflate. Under optimized conditions, products were obtained with high conversions and moderate to good enantioselectivities. The new C2-symmetric bis(phosphinite) ligands and their palladium(II) complexes were characterized using multinuclear NMR and Fourier transform infrared spectroscopies and elemental analysis.