175711-83-8 Usage
Description
4''-Chloro-2''-fluoroacetophenone is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its chemical structure, which includes a chloro group at the 4'' position and a fluoro group at the 2'' position, attached to an acetophenone backbone.
Uses
Used in Pharmaceutical Industry:
4''-Chloro-2''-fluoroacetophenone is used as a reagent for the synthesis of aminoazabenzimidazoles, which are a novel class of orally active antimalarial agents. Its unique chemical structure allows for the development of new and effective treatments against malaria.
Additionally, 4''-Chloro-2''-fluoroacetophenone is used in the preparation of the JAK2 Inhibitor, LY2784544 (L486570). 4''-CHLORO-2''-FLUOROACETOPHENONE is a potential therapeutic agent for the treatment of various diseases, including cancer, by targeting the Janus kinase 2 (JAK2) pathway, which plays a crucial role in cell signaling and is often dysregulated in various pathological conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 175711-83-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,7,1 and 1 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 175711-83:
(8*1)+(7*7)+(6*5)+(5*7)+(4*1)+(3*1)+(2*8)+(1*3)=148
148 % 10 = 8
So 175711-83-8 is a valid CAS Registry Number.
175711-83-8Relevant articles and documents
Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib
Wu, Qiuzi,Mao, Yang-Jie,Zhou, Kun,Wang, Shuang,Chen, Lei,Xu, Zhen-Yuan,Lou, Shao-Jie,Xu, Dan-Qian
supporting information, p. 4544 - 4547 (2021/05/17)
The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.
SUBSTITUTED TETRAHYDROCARBAZOLE AND CYCLOPENTANOINDOLE DERIVATIVES
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Page/Page column 23, (2010/02/12)
The present invention provides substituted tetrahydrocarbazole and cyclopentanoindole derivatives as antagonists of DP receptor, and as such are useful for the treatment of prostaglandin D2 mediated diseases such as rhinitis, asthma and nasal congestion.