177489-90-6

Basic information

• Product Name: (3-AMINO-1-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (3-AMINO-1-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER;3-BOC-AMINO-BUTYLAMINE;Carbamic acid, (3-amino-1-methylpropyl)-, 1,1-dimethylethyl ester (9CI);(3-Amino-1-methylpropyl)carbamic acid 1,1-dimethylethyl ester;3-Boc-amino-1-butylamine
• CAS NO: 177489-90-6
• Molecular Formula: C9H20N2O2
• Molecular Weight: 188.27
• Product Categories: N-BOC
• Mol File: 177489-90-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (3-AMINO-1-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (3-AMINO-1-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER(177489-90-6)
• EPA Substance Registry System: (3-AMINO-1-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER(177489-90-6)

Safety Data

• Hazardous Substances Data: 177489-90-6(Hazardous Substances Data)

Usage

General Description

(3-Amino-1-methyl-propyl)-carbamic acid tert-butyl ester is a chemical compound that is commonly used as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals. It is a carbamate ester, which is a type of compound that contains a carbamate functional group. This chemical is also known for its potential applications as an insecticide and herbicide. It should be handled and used with caution, as it may pose risks to human health and the environment if not properly managed.

Upstream product

• 177489-74-6 1-Azido-3-isocyanato-butane 
• 170367-68-7 (2-cyano-1(R)-methylethyl)carbamic acid, 1,1-dimethylethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 126301-16-4 (2R)-2-[(tert-butoxycarbonyl)amino]propyl methanesulfonate 
• 79069-13-9 (R)-2-tertbutoxycarbonylamino-1-propanol 
• 172695-22-6 (2-cyano-1(S)-methylethyl)carbamic acid, 1,1-dimethylethyl ester 
• 79069-13-9 (S)-2-t-butoxycarbonylaminopropan-1-ol 
• 126301-16-4 (2S)-2-[(tert-butoxycarbonyl)amino]propyl methanesulfonate 

Downstream Products

• 1327336-78-6 C₂₉H₃₇BrN₄O₄ 

Relevant articles and documents

TRIAZACYCLODODECANSULFONAMIDE ("TCD")-BASED PROTEIN SECRETION INHIBITORS

Provided herein are triazacyclododecansulfonamide ("TCD")-based protein secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I) and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.

Synthesis of novel optical isomers of α-methylpolyamines

Earlier unknown (R)- and (S)-α-methylspermidine, (R)- and (S)-α-methylspermine, (R,R)-, (S,S)-, and (R,S)-α,ω-dimethylspermine were synthesized in gram scale from readily available (R)- and (S)-2-aminopropanols in high overall yields.

α-methyl polyamines: Efficient synthesis and tolerance studies in vivo and in vitro. First evidence for dormant stereospecificity of polyamine oxidase

Efficient syntheses of metabolically stable α-methylspermidine 1, α-methylspermine 2, and bis-α,α-methylated spermine 3 starting from ethyl 3-aminobutyrate are described. The biological tolerance for these compounds was tested in wild-type mice and transgenic mice carrying the metallothionein promoter-driven spermidine/spermine N1- acetyltransferase gene (MT-SSAT). The efficient substitution of natural polyamines by their derivatives was confirmed in vivo with the rats harboring the same MT-SSAT transgene and in vitro with the immortalized fibroblasts derived from these animals. Enantiomers of previously unknown 1-amino-8-acetamido-5-azanonane dihydrochloride 4 were synthesized starting from enantiomerically pure (R)- and (S)-alaninols. The studies with recombinant human polyamine oxidase (PAO) showed that PAO (usually splits achiral substrates) strongly favors the (R)-isomer of 4 that demonstrates for the first time that the enzyme has hidden potency for stereospecificity.