1807455-76-0 Usage
Description
Rivaroxaban Impurity H, also known as 4''-Desmorpholino 4''-[N-(5-chloro-2-carboxy-thienyl) N-(5-Carboxy-3-oxa-pentyl)]amino Rivaroxaban, is an impurity found in Rivaroxaban (R538000), a novel antithrombotic agent. It is a highly potent and selective direct FXa inhibitor, which plays a significant role in the development and evaluation of the parent drug.
Uses
Used in Pharmaceutical Industry:
Rivaroxaban Impurity H is used as a reference compound for the development and validation of analytical methods in the pharmaceutical industry. Its presence in the parent drug, Rivaroxaban, necessitates the need for accurate quantification and control to ensure the safety, efficacy, and quality of the final drug product.
Used in Quality Control:
Rivaroxaban Impurity H is used as a quality control material to assess the performance of analytical methods and to ensure the reliability of the results obtained. This helps in maintaining the overall quality of the drug and meeting regulatory requirements.
Used in Research and Development:
Rivaroxaban Impurity H is used as a research tool in the development of new antithrombotic agents and in the study of the pharmacological properties of Rivaroxaban. Understanding the behavior and effects of this impurity can contribute to the optimization of the drug's therapeutic potential and the development of safer and more effective treatments for various conditions.
Used in Regulatory Compliance:
Rivaroxaban Impurity H is used in the context of regulatory compliance to demonstrate the ability of the manufacturing process to control and limit the presence of impurities in the final drug product. This is essential for obtaining marketing authorization and ensuring the drug's safety and efficacy for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1807455-76-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,7,4,5 and 5 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1807455-76:
(9*1)+(8*8)+(7*0)+(6*7)+(5*4)+(4*5)+(3*5)+(2*7)+(1*6)=190
190 % 10 = 0
So 1807455-76-0 is a valid CAS Registry Number.
1807455-76-0Relevant articles and documents
A [...] related substance diamine synthesis method
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, (2018/09/12)
The invention relates to a rivaroxaban related substance diamine which can be used as a reference substance to research and control rivaroxaban. The preparation method is simple, and the raw materials are easily available. The structural formula of the diamine is shown as follows: FORMULA shown in the description and the formula is C25H24CL2N4O4S2, and the molecular weight is 610.5. The rivaroxaban related substance diamine provided by the invention can be used as a reference substance for monitoring impurities of the rivaroxaban. The synthetic method for the rivaroxaban related substance diamine provided by the invention is simple to operate, has excellent practicality, and can bringrelatively good economic and social benefits.
Rivaroxaban impurities and preparing method and application thereof
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, (2017/08/28)
The invention discloses rivaroxaban impurities. The rivaroxaban impurities include the rivaroxaban impurity 6, the rivaroxaban impurity 10, the rivaroxaban impurity 11 and the rivaroxaban impurity 12; in addition, the invention discloses a preparing method and application of the rivaroxaban impurities. By means of the rivaroxaban impurities and the preparing method thereof, the basis is consolidated for rivaroxaban midbodies and raw material medicine and quality researching of compositions of the rivaroxaban impurities. The structural formula is shown in the specification.
