182822-62-4 Usage
Description
Rel-N-[4-Methoxy-3-[[[(2R,3R)-2-phenyl-3-piperidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide is a complex organic compound with a chemical structure that includes a phenyl group, a piperidinyl group, and a methanesulfonamide group. It is characterized by its stereochemistry at the 2R,3R positions and its ability to interact with specific receptors in the body.
Uses
Used in Pharmaceutical Industry:
Rel-N-[4-Methoxy-3-[[[(2R,3R)-2-phenyl-3-piperidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide is used as a neurokinin-1 (NK1) receptor antagonist for its potential role in treating conditions related to the central nervous system. It exhibits potent and selective antagonistic activity against the NK1 receptor, which is involved in various physiological processes and disorders.
Used in Research and Development:
In the field of research and development, this compound serves as a valuable tool for studying the function and role of the NK1 receptor in the body. It can be used to investigate the mechanisms of action of neurokinin receptors and their potential as therapeutic targets for various diseases and conditions.
Used in Drug Design and Optimization:
Rel-N-[4-Methoxy-3-[[[(2R,3R)-2-phenyl-3-piperidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide can be utilized in the design and optimization of new drugs targeting the NK1 receptor. Its unique chemical structure and receptor binding properties make it a promising starting point for the development of more effective and selective NK1 receptor antagonists.
Check Digit Verification of cas no
The CAS Registry Mumber 182822-62-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,2,8,2 and 2 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 182822-62:
(8*1)+(7*8)+(6*2)+(5*8)+(4*2)+(3*2)+(2*6)+(1*2)=144
144 % 10 = 4
So 182822-62-4 is a valid CAS Registry Number.
InChI:InChI=1/C21H29N3O3S/c1-24(28(3,25)26)18-11-12-20(27-2)17(14-18)15-23-19-10-7-13-22-21(19)16-8-5-4-6-9-16/h4-6,8-9,11-12,14,19,21-23H,7,10,13,15H2,1-3H3/t19-,21-/m0/s1
182822-62-4Relevant articles and documents
Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist
Rosen, Terry J.,Coffman, Karen J.,McLean, Stafford,Crawford, Rosemary T.,Bryce, Dianne K.,Gohda, Yoshiko,Tsuchiya, Megumi,Nagahisa, Atsushi,Nakane, Masami,Lowe III, John A.
, p. 281 - 284 (2007/10/03)
The synthesis and SAR of benzylamine side chain analogs of the NK-1 receptor antagonist CP-99,994 are described. The 5-trifluoromethoxy analog, CP-122,721, shows superior in vivo blockade of NK-1 receptor mediated responses.
