184685-22-1

Basic information

• Product Name: Methyl 2(R)-(1(S)-carboxy-3-phenylpropylamino)-4-(p-toluenesulfonylamino)butyrate
• CAS NO: 184685-22-1
• Molecular Weight: 448.54
• Mol File: 184685-22-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Methyl 2(R)-(1(S)-carboxy-3-phenylpropylamino)-4-(p-toluenesulfonylamino)butyrate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2(R)-(1(S)-carboxy-3-phenylpropylamino)-4-(p-toluenesulfonylamino)butyrate(184685-22-1)
• EPA Substance Registry System: Methyl 2(R)-(1(S)-carboxy-3-phenylpropylamino)-4-(p-toluenesulfonylamino)butyrate(184685-22-1)

Safety Data

• Hazardous Substances Data: 184685-22-1(Hazardous Substances Data)

Upstream product

• 184685-21-0 (R)-2-((S)-1-Benzyloxycarbonyl-3-phenyl-propylamino)-4-(toluene-4-sulfonylamino)-butyric acid methyl ester 
• 138333-10-5 (R)-4-Phenyl-2-trifluoromethanesulfonyloxy-butyric acid benzyl ester 
• 147091-71-2 (R)-2-tert-Butoxycarbonylamino-3-cyano-propionic acid methyl ester 
• 29678-81-7 (R)-2-hydroxy4-phenylbutanoic acid 

Relevant articles and documents

Hydroxamic acid compounds as metalloprotease and TNF inhibitors

The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrixmetalloproteinases, such as stromelysin and other matrix metalloproteinases, and also inhibit the production of tumor necrosis factor (TNF), and are therefore useful for the treatment of arthritis and other related inflammatory diseases. These novel compounds are represented by Formula I below: STR1