185448-73-1 Usage
General Description
2-Chloro-3',4'-bis(pivaloyloxy)acetophenone is a chemical compound with the molecular formula C18H21ClO6. It is a derivative of acetophenone and contains a chlorine atom and two pivaloyloxy groups. 2-Chloro-3',4'-bis(pivaloyloxy)acetophenone is commonly used as a precursor in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in organic chemistry for the introduction of the pivaloyloxy group into various molecules. Additionally, it has potential applications in the field of material science for the production of polymers and coatings. Due to its reactivity and potential health hazards, proper safety precautions should be taken when handling and working with this chemical.
Check Digit Verification of cas no
The CAS Registry Mumber 185448-73-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,4,4 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 185448-73:
(8*1)+(7*8)+(6*5)+(5*4)+(4*4)+(3*8)+(2*7)+(1*3)=171
171 % 10 = 1
So 185448-73-1 is a valid CAS Registry Number.
185448-73-1Relevant articles and documents
Soft β-adrenergic agonists for the topical treatment of psoriasis
Gill,Freeman,Irwin,Wilson
, p. 847 - 859 (1996)
The soft-drug 1 (R = Me, Et) and pro-soft-drug 3 have been prepared as models of topical anti-psoriatic β-adrenergic agonists. The chemical hydrolysis of 3 proceeded via the acid 18 with a maximum stability at apparent pH ~4.0. In the presence of PLCE, the required metabolism of 3 to the soft-drug 1 (R = Et) was achieved, which slowly degraded to the dihydroxy acid 2. Soft-drug 1 (R = Et) was poorly transported across a silicone membrane, whereas the pro-soft-drug 3 was more efficient and the rate increased over the donor apparent pH range 3-8. Soft-drug 1 (R = Et) was a full β-agonist on the guinea-pig tracheal preparation, whereas the pro-soft-drug 3 produced only slowly developing responses at high concentrations (> 10 μM).
