185448-78-6

Basic information

• Product Name: 2,2-Dimethyl-propionic acid 5-{2-[benzyl-(2-ethoxycarbonyl-ethyl)-amino]-acetyl}-2-(2,2-dimethyl-propionyloxy)-phenyl ester
• Synonyms: 2,2-Dimethyl-propionic acid 5-{2-[benzyl-(2-ethoxycarbonyl-ethyl)-amino]-acetyl}-2-(2,2-dimethyl-propionyloxy)-phenyl ester
• CAS NO: 185448-78-6
• Molecular Weight: 525.642
• Mol File: 185448-78-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2-Dimethyl-propionic acid 5-{2-[benzyl-(2-ethoxycarbonyl-ethyl)-amino]-acetyl}-2-(2,2-dimethyl-propionyloxy)-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethyl-propionic acid 5-{2-[benzyl-(2-ethoxycarbonyl-ethyl)-amino]-acetyl}-2-(2,2-dimethyl-propionyloxy)-phenyl ester(185448-78-6)
• EPA Substance Registry System: 2,2-Dimethyl-propionic acid 5-{2-[benzyl-(2-ethoxycarbonyl-ethyl)-amino]-acetyl}-2-(2,2-dimethyl-propionyloxy)-phenyl ester(185448-78-6)

Safety Data

• Hazardous Substances Data: 185448-78-6(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 3282-30-2 pivaloyl chloride 
• 99-40-1 2-chloro-3',4'-dihydroxyacetophenone 
• 539-74-2 Ethyl 3-bromopropionate 
• 23583-21-3 ethyl-3-benzylamino propionate 
• 185448-73-1 2,2-Dimethyl-propionic acid 5-(2-chloro-acetyl)-2-(2,2-dimethyl-propionyloxy)-phenyl ester 

Downstream Products

• 185448-86-6 2,2-Dimethyl-propionic acid 5-{2-[benzyl-(2-ethoxycarbonyl-ethyl)-amino]-1-hydroxy-ethyl}-2-(2,2-dimethyl-propionyloxy)-phenyl ester 
• 185448-94-6 2,2-Dimethyl-propionic acid 2-(2,2-dimethyl-propionyloxy)-5-[2-(2-ethoxycarbonyl-ethylamino)-1-hydroxy-ethyl]-phenyl ester 

Relevant articles and documents

Soft β-adrenergic agonists for the topical treatment of psoriasis

The soft-drug 1 (R = Me, Et) and pro-soft-drug 3 have been prepared as models of topical anti-psoriatic β-adrenergic agonists. The chemical hydrolysis of 3 proceeded via the acid 18 with a maximum stability at apparent pH ~4.0. In the presence of PLCE, the required metabolism of 3 to the soft-drug 1 (R = Et) was achieved, which slowly degraded to the dihydroxy acid 2. Soft-drug 1 (R = Et) was poorly transported across a silicone membrane, whereas the pro-soft-drug 3 was more efficient and the rate increased over the donor apparent pH range 3-8. Soft-drug 1 (R = Et) was a full β-agonist on the guinea-pig tracheal preparation, whereas the pro-soft-drug 3 produced only slowly developing responses at high concentrations (> 10 μM).