186028-79-5

Basic information

• Product Name: 2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one
• Synonyms: Methylenedioxymethcathinone hydrochloride;2-MethylaMino-1-(3;4-Methylenedioxyphenyl)propan-1-one;2-MethylaMino-1-(3,4-Methylenedioxyphenyl)propan-1;2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one;2-Methylamino-(3,4-Methylenedioxyphenyl)Propan-1-OneHydro;2-Methylamio-1-(3,4-Methylenedioxyphenyl)Propan-1-OneHcl(Methylone);2-METHYLAMINO-1-(3,4-METHYLENEDIOXIPHENYL)PROPAN-1-ONE
• CAS NO: 186028-79-5
• Molecular Formula: C11H13NO3
• Molecular Weight: 207.23
• Product Categories: Research Chemical;Chemical for Research;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 186028-79-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 350.1 °C at 760 mmHg
• Flash Point: 165.5 °C
• Appearance: /
• Density: 1.188 g/cm³
• Vapor Pressure: 4.5E-05mmHg at 25°C
• Refractive Index: 1.546
• PKA: 7.74±0.10(Predicted)
• CAS DataBase Reference: 2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one(186028-79-5)
• EPA Substance Registry System: 2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one(186028-79-5)

Safety Data

• Hazardous Substances Data: 186028-79-5(Hazardous Substances Data)

Usage

Description

2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one, also known as a ketone analogue of MDMA (Ecstasy), is a synthetic compound with a chemical structure that closely resembles MDMA. It possesses a 2-methylamino group and a 3,4-methylenedioxyphenyl group attached to a propanone backbone. 2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one is known for its almost antidepressant action, providing a pleasant and positive effect, although it lacks the unique "magic" of MDMA.

Uses

Used in Pharmaceutical Research:
2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one is used as a research chemical for studying the effects and mechanisms of action of MDMA and its analogues. Its structural similarity to MDMA allows scientists to explore potential therapeutic applications and understand the differences in their effects.
Used in Antidepressant Applications:
In the field of mental health, 2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one is used as a potential antidepressant agent. It is believed to have a positive impact on mood and emotional well-being, offering an alternative to traditional antidepressant medications.
Used in Recreational Settings:
2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one is also used recreationally for its euphoric and empathogenic effects, similar to those of MDMA. However,

InChI:InChI=1/C11H13NO3/c1-7(12-2)11(13)8-3-4-9-10(5-8)15-6-14-9/h3-5,7,12H,6H2,1-2H3

Upstream product

• 52190-28-0 1-(3,4-(methylenedioxy)phenyl)-2-bromopropan-1-one 
• 74-89-5 methylamine 
• 28281-49-4 3,4-methylenedioxypropiophenone 
• 274-09-9 Methylenedioxybenzene 
• 186028-79-5 1-(1,3-benzodioxol-5-yl)-2-(methylamino)propan-1-one 

Downstream Products

• 80535-73-5 3,4-Methylenedioxycathinone 
• 22930-83-2 3,4-dihydroxymethcathinone 
• 186028-79-5 S-(+)-methylone 
• 186028-79-5 R-(+)-methylone 

Relevant articles and documents

Successful use of a novel lux i-Amylose-1 chiral column for enantioseparation of “legal highs” by HPLC

Bath salts, fumigations, cleaners and air fresheners, behind these terms substances are hidden, which count as “Legal Highs”. These fancy names are used to pretend Legal Highs as harmless compounds, to circumvent legal regulations for marketing as well as to increase the sales. Besides classic illicit drugs of synthetic origin such as amphetamines, cocaine and MDMA, the trade of these compounds, also known as new psychoactive substances (NPS), is not uncommon today. In many countries, NPS are still not subject to drug control. Among them, there are stimulants such as new amphetamine derivatives or cathinones, which possess a chiral centre. Little is known about the fact that the two possible enantiomers may differ in their pharmacological effect. The aim of this study was to test a novel HPLC column for the enantioseparation of a set of 112 NPS coming from different chemical groups and collected by internet purchases during the years 2010–2018. The CSP, namely Lux 5?μm i-Amylose-1, LC Column 250 x 4.6?mm, was run in normal phase mode under isocratic conditions, UV detection was performed at 245?nm and 230?nm, injection volume was 10?μl and flow rate was 1?ml/min. With a mobile phase consisting of n-hexane/isopropanol/diethylamine (90:10:0.1), herein, 79 NPS were resolved into their enantiomers successfully, for 37 of them baseline resolution was achieved. After increase of lipophily of the mobile phase to 99:1:0.1, another 27 compounds were baseline separated. It was found that all separated NPS are traded as racemic compounds.

X-ray structures and computational studies of several cathinones

2-(Ethylamino)-1-(4-methylphenyl)propan-1-one (shortly named 4-MEC) (1a), 1-(1,3-benzodioxol-5-yl)-2-(methylamino)propan-1-one (shortly named methylone or 3,4-methylenedioxymethcathinone) (1b), 1-(3,4-dimethylphenyl)-2-(methylamino) propan-1-one (1c), 2-m