18620-04-7 Usage
Description
4-Thioanisolemagnesium bromide is a tan liquid chemical compound that serves as a crucial reagent in the synthesis of various pharmaceutical intermediates. It is known for its ability to facilitate the preparation of complex organic molecules, making it a valuable component in the field of organic chemistry and pharmaceutical research.
Uses
Used in Pharmaceutical Synthesis:
4-Thioanisolemagnesium bromide is used as a synthetic reagent for the preparation of key intermediates in the pharmaceutical industry. Its applications are primarily focused on the synthesis of complex organic molecules that serve as intermediates for the development of new drugs.
Used in the Synthesis of Mifepristone Analogs:
In the pharmaceutical industry, 4-Thioanisolemagnesium bromide is used as a synthetic reagent for the preparation of 3,3-Ethylenedioxy-5a-hydroxy-11b-[4-(thiomethoxy)phenyl]-estr-9-en-17-one, a key intermediate for the synthesis of mifepristone analogs. Mifepristone is a medication used in combination with misoprostol for the termination of pregnancy and for the treatment of Cushing's syndrome.
Used in the Synthesis of Aryl D-Glucofuranosides:
4-Thioanisolemagnesium bromide is also used as a synthetic reagent for the preparation of (1S)-1,4-Anhydro-2,3,5,6-tetra-O-benzyl-1-C-[4-chloro-3-(4-methylthiobenzyl)-phenyl]-D-glucitol, a key intermediate for the synthesis of aryl D-glucofuranosides. These compounds have been identified as potent inhibitors of human sodium-dependent glucose transport proteins (hSGLT2 and hSGLT1), which are targets for the treatment of type 2 diabetes and other metabolic disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 18620-04-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,2 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 18620-04:
(7*1)+(6*8)+(5*6)+(4*2)+(3*0)+(2*0)+(1*4)=97
97 % 10 = 7
So 18620-04-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H7S.BrH.Mg/c1-8-7-5-3-2-4-6-7;;/h3-6H,1H3;1H;/q;;+1/p-1/rC7H7BrMgS/c1-10-7-4-2-6(9-8)3-5-7/h2-5H,1H3
18620-04-7Relevant articles and documents
Copper-catalyzed difluoromethylation of β,γ-unsaturated carboxylic acids: An efficient allylic difluoromethylation
He, Zhengbiao,Hu, Mingyou,Luo, Tao,Li, Lingchun,Hu, Jinbo
supporting information, p. 11545 - 11547 (2013/01/15)
Not one but two! A new strategy for the regiospecific construction of compounds with allylic CF2H groups has been developed. The decarboxylative (phenylsulfonyl)difluoromethylation of β,γ- unsaturated carboxylic acids is catalyzed by a Lewis acid (CuCl 2·2 H2O), and the resulting product easily undergoes desulfonylation. Copyright
Methanediphosphonate derivative, its manufacturing process and its pharmaceutical applications
-
, (2008/06/13)
The present invention relates to a methanediphosphonate derivative, its manufacturing process and pharmaceutical applications, that is represented with the following formula: STR1 (wherein, B is either hydrogen, an alkyl group, hydroxyl group, alkoxy grou
