188047-58-7

Basic information

• Product Name: 1H-Pyrazole-4-carbonyl chloride, 5-chloro-3-methyl-1-phenyl-
• CAS NO: 188047-58-7
• Molecular Formula: C11H8Cl2N2O
• Molecular Weight: 255.103
• Mol File: 188047-58-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carbonyl chloride, 5-chloro-3-methyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carbonyl chloride, 5-chloro-3-methyl-1-phenyl-(188047-58-7)
• EPA Substance Registry System: 1H-Pyrazole-4-carbonyl chloride, 5-chloro-3-methyl-1-phenyl-(188047-58-7)

Safety Data

• Hazardous Substances Data: 188047-58-7(Hazardous Substances Data)

Upstream product

• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 
• 100-63-0 phenylhydrazine 
• 89-25-8 edaravone 
• 947-95-5 5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole 
• 1140-38-1 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4?carboxylic acid 
• 10026-13-8 phosphorus pentachloride 
• 83-10-3 antipyric acid 

Downstream Products

• 420124-23-8 1-[(5'-chloro-3'-methyl-1'-phenyl-1'H-pyrazol-4'-yl)carbonyl]-3-phenyl-1H-1,2,4-triazol-5-amine 
• 420124-37-4 5-chloro-3-methyl-1-phenyl-N-(5'-phenyl-1',2',4'-triazol-3'-yl)-1H-pyrazole-4-carboxamide 
• 420124-36-3 5-chloro-3-methyl-1-phenyl-N-(1',2',4'-triazol-3'-yl)-1H-pyrazole-4-carboxamide 
• 420124-22-7 1-[(5'-chloro-3'-methyl-1'-phenyl-1'H-pyrazol-4'-yl)carbonyl]-1H-1,2,4-triazol-5-amine 
• 1240508-53-5 (5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)(5-hydroxy-1-phenyl-1H-pyrazol-4-yl)methanone 
• 37703-62-1 (5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone 
• 1240508-59-1 1-(4-methoxybenzyl)-1H-pyrazol-5-yl 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxylate 
• 188047-59-8 C₁₂H₈ClN₃OS 
• 1392131-63-3 1-(4-bromo-2-(trifluoromethyl)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-64-4 1-(2-fluorobenzyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-65-5 1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-66-6 1-(2-fluoro-3-(trifluoromethyl)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 
• 1392131-67-7 1-(4-(trifluoromethylthio)phenyl)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbonyl)thiourea 

Relevant articles and documents

Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides

The pyrazole core has been recognized by their biological properties and included in the synthesis of modern agrochemicals. Part of these studies consists of making structural modifications to pesticides for commercial purposes to increase efficacy. In th

Pyrazole amides compound, preparation method therefor and application thereof

The present invention discloses a pyrazole amides compound. The structural formula of the compound is as shown in the description, wherein R is optionally substituted with one or more substituents of C1-C6 alkyl, alkoxy, halogen, nitro, and trifluoromethyl. The present invention also discloses a preparation method for the pyrazole amides compound. The pyrazole amides compound can be used for antibacterium, in particular for prevention and control of tomato late blight, tomato damping-off, corynespora cassiicola, botrytis cinerea, and cucumber sheath blight. The pyrazole amides compound can also be used for weeding, in particular for prevention and control of barnyard grass and rape.

Synthesis and bioactivity of pyrazole acyl thiourea derivatives

Sixteen novel pyrazole acyl thiourea derivatives 6 were synthesized from monomethylhydrazine (phenylhydrazine) and ethyl acetoacetate. The key 5-chloro-3- methyl-1-substituted-1H-pyrazole-4-carbonyl chloride intermediates 4 were first generated in four steps through cyclization, formylation, oxidation and acylation. Thess were then reacted with ammonium thiocyanate in the presence of PEG-400 to afford 5-chloro-3- methyl -1-substituted-1H-pyrazole-4-carbonyl isothiocyanates 5. Subsequent reaction with fluorinated aromatic amines resulted in the formation of the title compounds. The synthesized compound were unequivocally characterized by IR, 1H-NMR, 13C-NMR and elemental analysis and some of the synthesized compounds displayed good antifungal activities against Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica and anti-TMV activity in preliminary antifungal activity tests.