189197-69-1 Usage
Description
RO 48-8071, also known as a fumarate salt, is a compound obtained by combining Ro 48-8071 with one molar equivalent of fumaric acid. It is an inhibitor of lanosterol synthase, an enzyme involved in the synthesis of cholesterol.
Uses
Used in Pharmaceutical Industry:
RO 48-8071 is used as an inhibitor of lanosterol synthase for its potential role in the development of cholesterol-lowering drugs. By inhibiting lanosterol synthase, RO 48-8071 can help regulate cholesterol synthesis and potentially contribute to the treatment of hypercholesterolemia and related conditions.
Used in Research Applications:
RO 48-8071 is also used as a research tool in the study of cholesterol synthesis and related metabolic pathways. Its ability to inhibit lanosterol synthase makes it a valuable compound for understanding the role of this enzyme in cholesterol production and its potential as a therapeutic target for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 189197-69-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,1,9 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 189197-69:
(8*1)+(7*8)+(6*9)+(5*1)+(4*9)+(3*7)+(2*6)+(1*9)=201
201 % 10 = 1
So 189197-69-1 is a valid CAS Registry Number.
189197-69-1Relevant articles and documents
INDUCTION OF ESTROGEN RECEPTOR BETA BY CHOLESTEROL BIOSYNTHESIS INHIBITORS AND METHODS OF TREATMENT OF CANCER
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, (2014/01/17)
Disclosed herein are methods and compositions related to the discovery that cholesterol inhibitors induce the anti-proliferative protein, estrogen receptor beta (ERβ), in both ERα- positive and ERα-negative breast cancer cell lines, including triple negat
