1897-52-5

Basic information

• Product Name: 2,6-Difluorobenzonitrile
• Synonyms: 2,6-DIFLUOROBENZONIT;2,6-Difluorobenzonitrile99%;2,6-DIFLUOROBENZONITRILE, 97+%;2,6-DIFLUOROBENZNITRILE,97%;p-Phenylenediamine(1,4-Phenylenediamine);Benzonitrile, 2,6-difluoro-;2,6-Difluoro carbonitrile;6-Difluorobenzonitrile
• CAS NO: 1897-52-5
• Molecular Formula: C₇H₃F₂N
• Molecular Weight: 139.1
• EINECS: 217-589-7
• Product Categories: Aromatic Nitriles;Fluorobenzene;Nitrile;C6 to C7;Cyanides/Nitriles;Nitrogen Compounds;Fluorine series
• Mol File: 1897-52-5.mol
• Article Data: 33

Chemical Properties

• Melting Point: 25-28 °C(lit.)
• Boiling Point: 197-198 °C
• Flash Point: 176 °F
• Appearance: white to light yellow crystal powder
• Density: 1.246 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.23mmHg at 25°C
• Refractive Index: n20/D 1.4875(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Water Solubility: 1.87g/L at 19.85℃
• BRN: 2045292
• CAS DataBase Reference: 2,6-Difluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluorobenzonitrile(1897-52-5)
• EPA Substance Registry System: 2,6-Difluorobenzonitrile(1897-52-5)

Safety Data

• Hazard Codes: Xn,T,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-36/37/39
• RIDADR: 3439
• WGK Germany: 3
• TSCA: T
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 1897-52-5(Hazardous Substances Data)

Usage

Description

2,6-Difluorobenzonitrile is a halogenated benzonitrile compound characterized by its white to light yellow crystal powder appearance. It is known for its fungacidal activity and is the difluoro analogue of the herbicide Dichlobenil.

Uses

Used in Chemical Synthesis:
2,6-Difluorobenzonitrile is utilized as a key intermediate in the synthesis of various organic compounds and polymers, contributing to the development of new materials with enhanced properties.
Used in Agriculture:
In the agricultural industry, 2,6-Difluorobenzonitrile is used as a fungicide for its fungacidal activity, helping to protect crops from fungal infections and diseases.
Used in Polymer Synthesis:
2,6-Difluorobenzonitrile is used as a monomer in the synthesis of poly(cyanoaryl ethers) via the silyl-method, resulting in polymers with improved thermal stability and mechanical properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,6-Difluorobenzonitrile is used in the synthesis of 2-dimethylamino-6-fluorobenzamide, a compound with potential therapeutic applications.
Used in Material Science:
2,6-Difluorobenzonitrile is employed in the synthesis of phenolphthalein-modified polyarylene ether nitrile copolymers, which are used to create high-performance materials with unique properties for various applications.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C7H3F2N/c8-6-2-1-3-7(9)5(6)4-10/h1-3H

Synthetic route

2,6-difluorobenzamide (18063-03-1) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With Triethoxysilane; o-Ph2P(C6H4)Si(Me)2Fe(H)(PMe3)3 In tetrahydrofuran at 60℃; for 24h; Schlenk technique;	99%
With diphenylsilane; FeH(PMe3)2(SiPh(NCH2PPh2)2C6H4) In tetrahydrofuran at 70℃; for 24h; Schlenk technique; Inert atmosphere;	90%
With Triethoxysilane; [cis-Fe(H)(SPh)(PMe3)4] In tetrahydrofuran at 60℃; for 24h; Inert atmosphere;	87%

C26H18AuF2N2P → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
In 1,4-dioxane at 100℃; for 2h; Kinetics; Solvent; Temperature; Inert atmosphere; Schlenk technique; Sealed tube;	99%

2,6-dichloro-benzonitrile (1194-65-6) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
Stage #1: 2,6-dichloro-benzonitrile With 1-Ethylpyridinium chloride In dimethyl sulfoxide; toluene at 110℃; for 2h; Stage #2: With potassium fluoride In dimethyl sulfoxide; toluene at 90 - 150℃; for 15h; Reagent/catalyst; Temperature; Solvent;	98.34%
With potassium fluoride; tetrabutylammomium bromide at 170℃; for 12h;	91%
With potassium fluoride; immobilized pyridinium salt In sulfolane at 180℃; for 4h;	82%

trimethylsilyl cyanide (7677-24-9) + C34H43AuF3NP(1+)*F6Sb(1-) → 2,6 difluorobenzonitrile (1897-52-5) + F6Sb(1-)*C32H49AuN2PSi(1+)

Conditions	Yield
In dichloromethane-d2 at 25℃; for 3h; Glovebox;	A 96% B n/a

2,6-dichloro-benzonitrile (1194-65-6) + tetrakis(diethylamino)phosphonium bromide (81175-49-7) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With potassium fluoride; dimethyl sulfoxide In sulfolane; chlorobenzene	93%

2,6-dichloro-benzonitrile (1194-65-6) + tetrakis(diethylamino)phosphonium bromide (81175-49-7) + 4-Fluoronitrobenzene (350-46-9) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With potassium fluoride In sulfolane; chlorobenzene	91%

Triethoxysilane (998-30-1) + 2,6-difluorobenzamide (18063-03-1) → 2,6 difluorobenzonitrile (1897-52-5) + C12H30O7Si2

Conditions	Yield
With C22H48FeOP4 In tetrahydrofuran at 60℃; for 24h; Inert atmosphere; Schlenk technique;	A 75% B n/a

2-chloro-6-nitrobenzonitrile (6575-07-1) → 2-chloro-6-fluorobenzonitrile (668-45-1) + 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With biphenyl; tetramethylammonium fluoride In N,N-dimethyl acetamide at 60℃; for 0.666667h;	A 72% B 5%
With tetrabutyl ammonium fluoride In tetrahydrofuran for 1.5h; Ambient temperature;	A 75 % Chromat. B 25 % Chromat.

2,6-difluoro-benzaldehyde oxime (19064-16-5) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With N-methyl-N,N,N-triethylammonium methylsulfate In acetonitrile at 22℃; Electrolysis;	47%

1,3-Difluorobenzene (372-18-9) + N,N-dimethyl-formamide (68-12-2, 33513-42-7) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
Stage #1: 1,3-Difluorobenzene With lithium diisopropyl amide In tetrahydrofuran at 20℃; for 2h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 0℃; for 2h; Stage #3: With ammonia; iodine In tetrahydrofuran; water at 0 - 20℃; for 2h;	42%

C7H2F3N(1-) (96606-37-0) → 2,6 difluorobenzonitrile (1897-52-5) + 3,3',5,5'-tetrafluoro-[1,1'-biphenyl]-4,4'-dicarbonitrile (116720-37-7)

Conditions	Yield
In N,N-dimethyl-formamide Rate constant; kfr;

2,6-difluorobenzyl chloride (697-73-4) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With air; ammonia; water; V-8Ti-xO at 250℃; Product distribution; various temperatures, other catalyst;

2-chloro-6-fluorobenzonitrile (668-45-1) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With tetramethylammonium hydrogen difluoride In N,N-dimethyl acetamide at 120℃; for 3h;	77 % Chromat.

2-chloro-6-nitrobenzonitrile (6575-07-1) → 2-chloro-6-fluorobenzonitrile (668-45-1) + 2,6 difluorobenzonitrile (1897-52-5) + 3-chloro-2-cyanophenol (89999-90-6) + 2-Fluoro-6-hydroxybenzonitrile (140675-43-0)

Conditions	Yield
With tetramethylammonium fluoride In dimethyl sulfoxide at 100℃; for 1h; Fluorination;

2-chloro-6-fluorobenzonitrile (668-45-1) → 2,6 difluorobenzonitrile (1897-52-5) + 3-chloro-2-cyanophenol (89999-90-6) + 2-Fluoro-6-hydroxybenzonitrile (140675-43-0)

Conditions	Yield
With tetramethylammonium fluoride In dimethyl sulfoxide at 100℃; for 0.5h; Fluorination;

2-chloro-6-nitrobenzonitrile (6575-07-1) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: tetramethylammonium fluoride / dimethylsulfoxide / 1 h / 100 °C 2: tetramethylammonium fluoride / dimethylsulfoxide / 0.5 h / 100 °C View Scheme

1,3-Difluorobenzene (372-18-9) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
Multi-step reaction with 4 steps 1: (i) nBuLi, (ii) /BRN= 1900390/ 2: SOCl2 3: NH3 4: SOCl2 / dimethylformamide View Scheme

2,6-difluorobenzoylchloride (18063-02-0) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: NH3 2: SOCl2 / dimethylformamide View Scheme

2,6-difluorobenzoic acid (385-00-2) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: SOCl2 2: NH3 3: SOCl2 / dimethylformamide View Scheme

2,6-dichloro-benzonitrile (1194-65-6) → 2-chloro-6-fluorobenzonitrile (668-45-1) + 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With potassium fluoride; 1-butyl-3-methylimidazolium tetrafluoroborate In sulfolane at 180℃; for 18h; Product distribution / selectivity;	A 45 %Chromat. B 52 %Chromat.
1-butyl-3-methylimidazolium hexafluorophosphate In sulfolane at 180℃; for 18h; Product distribution / selectivity;	A 79 %Chromat. B 19 %Chromat.

dimethyl-di(ethoxypolyoxypropyl)ammonium chloride + 2,6-dichloro-benzonitrile (1194-65-6) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With potassium fluoride In 5,5-dimethyl-1,3-cyclohexadiene

trimethyl(ethoxypolyoxypropyl)ammonium chloride + 2,6-dichloro-benzonitrile (1194-65-6) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With potassium fluoride In 5,5-dimethyl-1,3-cyclohexadiene

3-chloro-2,6-difluorobenzonitrile (86225-73-2) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With sodium hydroxide; palladium-carbon catalyst In water

2,4,6-trifluorobenzonitrile (96606-37-0) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With Dimethylphenylsilane; o-phenylenebis(diphenylphosphine); potassium tert-butylate; copper(l) chloride In tetrahydrofuran for 12h; Inert atmosphere; Reflux; regioselective reaction;	100 %Spectr.

2,6-difluorobenzylamine (69385-30-4) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With copper(l) iodide; oxygen In dichloromethane at 20℃; under 760.051 Torr; for 6h; Sealed tube;	74 %Spectr.

potassiumhexacyanoferrate(II) trihydrate + C12H3F7O3S → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In N,N-dimethyl-formamide at 40℃; for 3h; Sealed tube; Green chemistry;

C26H18AuF2N2P → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
In 1,4-dioxane at 65℃; Kinetics; Inert atmosphere; Schlenk technique; Sealed tube;

2,6-dichlorotoluene (118-69-4) → 2,6 difluorobenzonitrile (1897-52-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: phosphorus pentachloride; chlorine / 150 °C 2: acetic acid; zinc(II) chloride; hydroxylamine hydrochloride; sodium acetate / 8 h / Reflux 3: potassium fluoride; tetrabutylammomium bromide / 12 h / 170 °C View Scheme

2,6 difluorobenzonitrile (1897-52-5) → 2,6-difluorobenzamide (18063-03-1)

Conditions	Yield
With water; nitrile hydratase from Rhodococcus rhodochrous J1 at 25℃; for 22h; KH2PO4-K2HPO4 puffer pH=8.0;	100%
With dihydrogen peroxide; sodium hydroxide at 50℃; for 5h; Temperature;	91.2%
With sulfuric acid at 70℃; for 4h;	90%

2,6 difluorobenzonitrile (1897-52-5) + sodium methylate (124-41-4) → 2-fluoro-6-methoxybenzonitrile (94088-46-7)

Conditions	Yield
In methanol at 0 - 20℃;	99%
In methanol at 0℃;	86%
In methanol at 0 - 20℃;

2,6 difluorobenzonitrile (1897-52-5) → 2-amino-6-fluorobenzonitrile (77326-36-4)

Conditions	Yield
With ammonia In dimethyl sulfoxide at 80℃; for 80h; closed bottle;	99%
With ammonia In ethanol at 140℃; under 10343.2 Torr; for 6h;	97%
With ammonia In dimethyl sulfoxide at 80 - 120℃;	97.5%

2,6 difluorobenzonitrile (1897-52-5) + 2,2-bis(4-hydroxyphenyl)propane bistrimethylsilyl ether (4387-16-0) → polymer; monomer(s): 1,1-bis(4-trimethylsilyloxyphenyl)-1-methylethane; 2,6-difluorobenzonitrile

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 140 - 145℃; for 48h;	99%

2,6 difluorobenzonitrile (1897-52-5) + (+/-)-α-(o-(trifluoromethyl)phenyl)ethyl alcohol (79756-81-3) → 2-fluoro-6-[1-(2-trifluoromethylphenyl)-ethoxy]-benzonitrile (872181-46-9)

Conditions	Yield
Stage #1: (+/-)-α-(o-(trifluoromethyl)phenyl)ethyl alcohol With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 0.75h; Stage #2: 2,6 difluorobenzonitrile In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 2.33333h;	99%
With sodium hydride In N,N-dimethyl-formamide at 0℃; for 2h;

2,6 difluorobenzonitrile (1897-52-5) → 2-fluoro-6-[4-(2-fluorobenzyl)cyclohexylmethoxy]benzonitrile

Conditions	Yield
Stage #1: [4-(2-fluorobenzyl)cyclohexyl]methanol With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2.03333h; Stage #2: 2,6 difluorobenzonitrile In N,N-dimethyl-formamide at 0℃; for 2.01667h;	98%

2,6 difluorobenzonitrile (1897-52-5) + ethylamine (75-04-7) → 2-ethylamino-6-fluorobenzonitrile (119584-72-4)

Conditions	Yield
In dimethyl sulfoxide for 4h; Ambient temperature;	97%

2,6 difluorobenzonitrile (1897-52-5) + thiophenol (108-98-5) → 2,6-bis(phenylthio)benzonitrile (1271825-04-7)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 25℃;	97%

4-Octyne (1942-45-6) + 2,6 difluorobenzonitrile (1897-52-5) → (Z)-3-(2,6-difluorophenyl)-2-propylhex-2-enenitrile (1453501-01-3)

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0); triphenylborane; bis[2-(diphenylphosphino)phenyl] ether at 100℃; for 8h; Inert atmosphere; chemoselective reaction;	97%

nitromethane (75-52-5) + 2,6 difluorobenzonitrile (1897-52-5) → (Z)-1-(2,6-difluorophenyl)-2-nitroethen-1-amine

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene at 85℃; for 0.5h; Aza-Henry Reaction; Molecular sieve;	97%

phenoxazine (135-67-1) + 2,6 difluorobenzonitrile (1897-52-5) → 2,6-di(10H-phenoxazin-10-yl)benzonitrile

Conditions	Yield
With sodium ethanolate In N,N-dimethyl-formamide at 70 - 150℃; for 48h;	97%
With sodium hydride In hexane; N,N-dimethyl-formamide; mineral oil for 10h; Inert atmosphere;	82%

2,6 difluorobenzonitrile (1897-52-5) → 2-fluorobenzonitrile (394-47-8)

Conditions	Yield
With 9,10-phenanthrenequinone In N,N-dimethyl-formamide for 8.25h; Electrochemical reaction;	95.7%

1,1,1-tris(4-trimethylsilyloxyphenyl)ethane + 2,6 difluorobenzonitrile (1897-52-5) → polymer, product of 1,1,1-tris(4-trimethylsilyloxyphenyl)ethane polycondensation with 2,6-difluorobenzonitrile at 140 - 145 deg C for 48 h, monomers feed ratio 1.0:1.1; monomer(s): 1,1,1-tris(4-trimethylsilyloxyphenyl)ethane; 2,6-difluorobenzonitrile

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 140 - 145℃; for 48h;	95%

2,6 difluorobenzonitrile (1897-52-5) + benzyl alcohol (100-51-6) → 2-(benzyloxy)-6-fluorobenzonitrile (94088-45-6)

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0 - 20℃;	95%

2,6 difluorobenzonitrile (1897-52-5) + methylmagnesium chloride (676-58-4) → 2,6-difluoroacetophenone (13670-99-0)

Conditions	Yield
Stage #1: 2,6 difluorobenzonitrile; methylmagnesium chloride In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene at 20℃; for 20h; Inert atmosphere; Stage #2: With sulfuric acid In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; water at 50℃;	95%
Stage #1: 2,6 difluorobenzonitrile; methylmagnesium chloride In tetrahydrofuran; toluene at 36 - 40℃; for 5h; Inert atmosphere; Stage #2: With sulfuric acid; water In tetrahydrofuran; toluene at 27 - 30℃; for 2.5h; Inert atmosphere;	93 %Chromat.

1-methyl-1H-indole-2,3-dione (2058-74-4) + 2,6 difluorobenzonitrile (1897-52-5) + dimedone (126-81-8) → 1-fluoro-1',10,10-trimethyl-10,11-dihydro-5H-spiro[indazolo[3,2-b]quinazoline-7,3'-indoline]-2',8(9H)-dione

Conditions	Yield
Stage #1: 2,6 difluorobenzonitrile With hydrazine In ethanol at 80℃; for 0.5h; Green chemistry; Stage #2: 1-methyl-1H-indole-2,3-dione; dimedone With toluene-4-sulfonic acid In ethanol at 80℃; for 4h; Green chemistry;	95%

10H-phenothiazine (92-84-2) + 2,6 difluorobenzonitrile (1897-52-5) → C31H19N3S2

Conditions	Yield
With sodium ethanolate In N,N-dimethyl-formamide at 70 - 150℃; for 48h;	95%

2,6 difluorobenzonitrile (1897-52-5) → 3-amino-4-fluoro-1H-indazole

Conditions	Yield
With hydrazine hydrate In ethanol at 90℃; for 4h; Inert atmosphere;	94%
With hydrazine hydrate In ethanol at 90℃; for 4h; Inert atmosphere;	94%

2,6 difluorobenzonitrile (1897-52-5) + N-cyclopentyl-3-(hydroxymethyl)-2-oxopiperidine-3-carboxamide → 3-((2-cyano-3-fluorophenoxy)methyl)-N-cyclopentyl-2-oxopiperidine-3-carboxamide

Conditions	Yield
Stage #1: N-cyclopentyl-3-(hydroxymethyl)-2-oxopiperidine-3-carboxamide With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h; Inert atmosphere; Stage #2: 2,6 difluorobenzonitrile In tetrahydrofuran; mineral oil at 0 - 20℃; Inert atmosphere;	94%

2,6 difluorobenzonitrile (1897-52-5) + indole-2,3-dione (91-56-5) + dimedone (126-81-8) → 1-fluoro-10,10-dimethyl-10,11-dihydro-5H-spiro[indazolo[3,2-b]quinazoline-7,3'-indoline]-2',8(9H)-dione

Conditions	Yield
Stage #1: 2,6 difluorobenzonitrile With hydrazine In ethanol at 80℃; for 0.5h; Green chemistry; Stage #2: indole-2,3-dione; dimedone With toluene-4-sulfonic acid In ethanol at 80℃; for 4h; Green chemistry;	94%

2,6 difluorobenzonitrile (1897-52-5) + 3-Trifluoromethylphenol (98-17-9) → 2-fluoro-6-(3-(trifluoromethyl)phenoxy)benzonitrile

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 16h;	93%

2,6 difluorobenzonitrile (1897-52-5) + 9,9-bis(4-hydroxyphenyl)fluorene (3236-71-3) → C135H79F2N5O8

Conditions	Yield
Stage #1: 2,6 difluorobenzonitrile; 9,9-bis(4-hydroxyphenyl)fluorene With potassium carbonate In N,N-dimethyl acetamide; toluene at 140 - 165℃; for 5h; Inert atmosphere; Dean-Stark; Stage #2: 2,6 difluorobenzonitrile In N,N-dimethyl acetamide; toluene at 160℃; for 1h; Inert atmosphere; Dean-Stark;	92%

5-methoxyisatine (39755-95-8) + 2,6 difluorobenzonitrile (1897-52-5) + dimedone (126-81-8) → 1-fluoro-5'-methoxy-10,10-dimethyl-10,11-dihydro-5H-spiro[indazolo[3,2-b]quinazoline-7,3'-indoline]-2',8(9H)-dione

Conditions	Yield
Stage #1: 2,6 difluorobenzonitrile With hydrazine In ethanol at 80℃; for 0.5h; Green chemistry; Stage #2: 5-methoxyisatine; dimedone With toluene-4-sulfonic acid In ethanol at 80℃; for 4h; Green chemistry;	92%

2,6 difluorobenzonitrile (1897-52-5) + guanidine hydrogen carbonate (124-46-9, 20734-13-8, 100224-74-6, 593-85-1) → 2,4-diamino-5-fluoroquinazoline (119584-70-2)

Conditions	Yield
In N,N-dimethyl acetamide at 140 - 142℃; for 5h;	91%
In N,N-dimethyl acetamide at 140℃; for 8h;	77%

Upstream product

• 18063-03-1 2,6-difluorobenzamide 
• 6575-07-1 2-chloro-6-nitrobenzonitrile 
• 1194-65-6 2,6-dichloro-benzonitrile 
• 96606-37-0 C₇H₂F₃N^(1-) 
• 697-73-4 2,6-difluorobenzyl chloride 
• 668-45-1 2-chloro-6-fluorobenzonitrile 
• 372-18-9 1,3-Difluorobenzene 
• 18063-02-0 2,6-difluorobenzoylchloride 
• 385-00-2 2,6-difluorobenzoic acid 
• 81175-49-7 tetrakis(diethylamino)phosphonium bromide 
• 350-46-9 4-Fluoronitrobenzene 
• 86225-73-2 3-chloro-2,6-difluorobenzonitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 96606-37-0 2,4,6-trifluorobenzonitrile 

Downstream Products

• 144899-92-3 N,N'-di(2-cyano-3-fluorophenyl)piperazine 
• 84162-93-6 1-Methyl-4-(2,6-difluorobenzoyl)piperidine 
• 96994-73-9 2-(dimethylamino)-6-fluorobenzonitrile 
• 51271-33-1 2,6-di(methylthio)benzonitrile 
• 119584-71-3 2-fluoro-6-(methylthio)benzonitrile 
• 119584-74-6 2-fluoro-6-(2,2,2-trifluoroethoxy)benzonitrile 
• 137578-19-9 2-fluoro-6-(2,2,3,3,3-pentafluoropropoxy)benzonitrile 
• 137553-48-1 4-amino-5-fluoroquinazoline 
• 119584-70-2 2,4-diamino-5-fluoroquinazoline 
• 13670-99-0 2,6-difluoroacetophenone 
• 94088-46-7 2-fluoro-6-methoxybenzonitrile 
• 119584-73-5 2-ethoxy-6-fluorobenzonitrile 
• 144899-96-7 ethyl 2-cyano-3-fluorophenylaminoacetate 
• 144899-97-8 N-ethoxycarbonylmethyl 2-cyano-3-fluorophenylaminoacetamide 

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A new family of cationic, bidentate (P^N)gold(III) fluoride complexes has been prepared and a detailed characterization of the gold-fluoride bond has been carried out. Our results correlate with the observed reactivity of the fluoro ligand, which undergoes facile exchange with both cyano and acetylene nucleophiles. The resulting (P^N)arylgold(III)C(sp) complexes have enabled the first study of reductive elimination on (P^N)gold(III) systems, which demonstrated that C(sp2)?C(sp) bond formation occurs at higher rates than those reported for analogous phosphine-based monodentate systems.

Method for dehydrating primary amide into nitriles under catalysis of cobalt

The invention provides a method for dehydrating primary amide into nitrile. The method comprises the following steps: mixing primary amide (II), silane, sodium triethylborohydride, aminopyridine imine tridentate nitrogen ligand cobalt complex (I) and a reaction solvent under the protection of inert gas, carrying out reacting at 60-100 DEG C for 6-24 hours, and post-treating reaction liquid to obtain a nitrile compound (III). According to the invention, an effective method for preparing nitrile compounds by cobalt-catalyzed primary amide dehydration reaction by using the novel aminopyridine imine tridentate nitrogen ligand cobalt complex catalyst is provided; and compared with existing methods, the method has the advantages of simple operation, mild reaction conditions, wide application range of reaction substrates, high selectivity, stable catalyst, high efficiency, and relatively high practical application value in synthesis.

Palladium-Catalyzed Cyanation under Mild Conditions: A Case Study to Discover Appropriate Substrates among Halides and Pseudohalides

A case study has been effectively carried out to identify a suitable substrate among halides and pseudohalides for the palladium-catalyzed cyanation reactions under mild conditions. Among the various substrates considered for evaluation, aryl pentafluorobenzenesulfonates and nonaflates were identified to be the best substrates when compared to corresponding halides and pseudohalides. The substoichiometric use of nontoxic, environmentally benign potassium hexacyanoferrate as a cyanide source and exceptionally milder conditions further highlights the significance of the protocol developed. A wide range of electronically biased and sterically challenging substrates provided the corresponding the nitriles in good to excellent yields.