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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2,6-Difluorobenzonitrile Manufacturer/High quality/Best price/In stock

Cas:1897-52-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,6-Difluorobenzonitrile supplier in China

Cas:1897-52-5

Min.Order:1 Metric Ton

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Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, c

1897-52-5 2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:1 Kilogram

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,6-difluorobenzonitrile

Cas:1897-52-5

Min.Order:1

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Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 2,6-Difluorobenzonitrile 1897-52-5 ISO Manufacturer

Cas:1897-52-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:1 Kilogram

FOB Price: $5.0

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:1 Metric Ton

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

2,6-Difluorobenzonitrile Manufacturer/High quality/Best price/In stock CAS NO.1897-52-5

Cas:1897-52-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

1897-52-5 2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

2, 6-Difluorobenzonitrile CAS No. 1897-52-5

Cas:1897-52-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 1897-52-5 with fast shipping

Cas:1897-52-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material 2,6-Difluorobenzonitrile CAS 1897-52-5

Cas:1897-52-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Liquid Storage:Store in sealed containers at cool & dry plac

2, 6-Diflurobenzonitrile CAS 1897-52-5

Cas:1897-52-5

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2,6-Difluorobenzonitrile 1897-52-5

Cas:1897-52-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:1 Kilogram

FOB Price: $70.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2,6-Difluorobenzonitrile CAS:1897-52-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic i

2,6-Difluorobenzonitrile CAS:1897-52-5

Cas:1897-52-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

1.Best quality in your requirement 2.Competitive price in China market 3.mature Technical support 4.Professional logistic support All we want is win-win business. Send yr. inquiries, you will get it! Appearance:white powder Storage:Dry and ventil

Factory Supply 2, 6-Diflurobenzonitrile CAS 1897-52-5

Cas:1897-52-5

Min.Order:20 Kilogram

FOB Price: $24.0 / 25.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:0

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c

2,6-DifluorobenzonitrileCAS: 1897-52-5

Cas:1897-52-5

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:0 Metric Ton

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2,6-DIFLUOROBENZONITRILE

Cas:1897-52-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:1 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2,6-Difluorobenzonitrile/High quality/Best price

Cas:1897-52-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2,6-Difluorobenzonitrile

Cas:1897-52-5

Min.Order:10 Gram

FOB Price: $100.0

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Synthetic route

2,6-difluorobenzamide
18063-03-1

2,6-difluorobenzamide

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With Triethoxysilane; o-Ph2P(C6H4)Si(Me)2Fe(H)(PMe3)3 In tetrahydrofuran at 60℃; for 24h; Schlenk technique;99%
With diphenylsilane; FeH(PMe3)2(SiPh(NCH2PPh2)2C6H4) In tetrahydrofuran at 70℃; for 24h; Schlenk technique; Inert atmosphere;90%
With Triethoxysilane; [cis-Fe(H)(SPh)(PMe3)4] In tetrahydrofuran at 60℃; for 24h; Inert atmosphere;87%
C26H18AuF2N2P

C26H18AuF2N2P

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
In 1,4-dioxane at 100℃; for 2h; Kinetics; Solvent; Temperature; Inert atmosphere; Schlenk technique; Sealed tube;99%
2,6-dichloro-benzonitrile
1194-65-6

2,6-dichloro-benzonitrile

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
Stage #1: 2,6-dichloro-benzonitrile With 1-Ethylpyridinium chloride In dimethyl sulfoxide; toluene at 110℃; for 2h;
Stage #2: With potassium fluoride In dimethyl sulfoxide; toluene at 90 - 150℃; for 15h; Reagent/catalyst; Temperature; Solvent;
98.34%
With potassium fluoride; tetrabutylammomium bromide at 170℃; for 12h;91%
With potassium fluoride; immobilized pyridinium salt In sulfolane at 180℃; for 4h;82%
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

C34H43AuF3NP(1+)*F6Sb(1-)

C34H43AuF3NP(1+)*F6Sb(1-)

A

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

B

F6Sb(1-)*C32H49AuN2PSi(1+)

F6Sb(1-)*C32H49AuN2PSi(1+)

Conditions
ConditionsYield
In dichloromethane-d2 at 25℃; for 3h; Glovebox;A 96%
B n/a
2,6-dichloro-benzonitrile
1194-65-6

2,6-dichloro-benzonitrile

tetrakis(diethylamino)phosphonium bromide
81175-49-7

tetrakis(diethylamino)phosphonium bromide

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With potassium fluoride; dimethyl sulfoxide In sulfolane; chlorobenzene93%
2,6-dichloro-benzonitrile
1194-65-6

2,6-dichloro-benzonitrile

tetrakis(diethylamino)phosphonium bromide
81175-49-7

tetrakis(diethylamino)phosphonium bromide

4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With potassium fluoride In sulfolane; chlorobenzene91%
Triethoxysilane
998-30-1

Triethoxysilane

2,6-difluorobenzamide
18063-03-1

2,6-difluorobenzamide

A

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

B

C12H30O7Si2

C12H30O7Si2

Conditions
ConditionsYield
With C22H48FeOP4 In tetrahydrofuran at 60℃; for 24h; Inert atmosphere; Schlenk technique;A 75%
B n/a
2-chloro-6-nitrobenzonitrile
6575-07-1

2-chloro-6-nitrobenzonitrile

A

2-chloro-6-fluorobenzonitrile
668-45-1

2-chloro-6-fluorobenzonitrile

B

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With biphenyl; tetramethylammonium fluoride In N,N-dimethyl acetamide at 60℃; for 0.666667h;A 72%
B 5%
With tetrabutyl ammonium fluoride In tetrahydrofuran for 1.5h; Ambient temperature;A 75 % Chromat.
B 25 % Chromat.
2,6-difluoro-benzaldehyde oxime
19064-16-5

2,6-difluoro-benzaldehyde oxime

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With N-methyl-N,N,N-triethylammonium methylsulfate In acetonitrile at 22℃; Electrolysis;47%
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
Stage #1: 1,3-Difluorobenzene With lithium diisopropyl amide In tetrahydrofuran at 20℃; for 2h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 0℃; for 2h;
Stage #3: With ammonia; iodine In tetrahydrofuran; water at 0 - 20℃; for 2h;
42%
C7H2F3N(1-)
96606-37-0

C7H2F3N(1-)

A

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

B

3,3',5,5'-tetrafluoro-[1,1'-biphenyl]-4,4'-dicarbonitrile
116720-37-7

3,3',5,5'-tetrafluoro-[1,1'-biphenyl]-4,4'-dicarbonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide Rate constant; kfr;
2,6-difluorobenzyl chloride
697-73-4

2,6-difluorobenzyl chloride

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With air; ammonia; water; V-8Ti-xO at 250℃; Product distribution; various temperatures, other catalyst;
2-chloro-6-fluorobenzonitrile
668-45-1

2-chloro-6-fluorobenzonitrile

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With tetramethylammonium hydrogen difluoride In N,N-dimethyl acetamide at 120℃; for 3h;77 % Chromat.
2-chloro-6-nitrobenzonitrile
6575-07-1

2-chloro-6-nitrobenzonitrile

A

2-chloro-6-fluorobenzonitrile
668-45-1

2-chloro-6-fluorobenzonitrile

B

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

C

3-chloro-2-cyanophenol
89999-90-6

3-chloro-2-cyanophenol

D

2-Fluoro-6-hydroxybenzonitrile
140675-43-0

2-Fluoro-6-hydroxybenzonitrile

Conditions
ConditionsYield
With tetramethylammonium fluoride In dimethyl sulfoxide at 100℃; for 1h; Fluorination;
2-chloro-6-fluorobenzonitrile
668-45-1

2-chloro-6-fluorobenzonitrile

A

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

B

3-chloro-2-cyanophenol
89999-90-6

3-chloro-2-cyanophenol

C

2-Fluoro-6-hydroxybenzonitrile
140675-43-0

2-Fluoro-6-hydroxybenzonitrile

Conditions
ConditionsYield
With tetramethylammonium fluoride In dimethyl sulfoxide at 100℃; for 0.5h; Fluorination;
2-chloro-6-nitrobenzonitrile
6575-07-1

2-chloro-6-nitrobenzonitrile

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetramethylammonium fluoride / dimethylsulfoxide / 1 h / 100 °C
2: tetramethylammonium fluoride / dimethylsulfoxide / 0.5 h / 100 °C
View Scheme
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: (i) nBuLi, (ii) /BRN= 1900390/
2: SOCl2
3: NH3
4: SOCl2 / dimethylformamide
View Scheme
2,6-difluorobenzoylchloride
18063-02-0

2,6-difluorobenzoylchloride

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NH3
2: SOCl2 / dimethylformamide
View Scheme
2,6-difluorobenzoic acid
385-00-2

2,6-difluorobenzoic acid

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SOCl2
2: NH3
3: SOCl2 / dimethylformamide
View Scheme
2,6-dichloro-benzonitrile
1194-65-6

2,6-dichloro-benzonitrile

A

2-chloro-6-fluorobenzonitrile
668-45-1

2-chloro-6-fluorobenzonitrile

B

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With potassium fluoride; 1-butyl-3-methylimidazolium tetrafluoroborate In sulfolane at 180℃; for 18h; Product distribution / selectivity;A 45 %Chromat.
B 52 %Chromat.
1-butyl-3-methylimidazolium hexafluorophosphate In sulfolane at 180℃; for 18h; Product distribution / selectivity;A 79 %Chromat.
B 19 %Chromat.
dimethyl-di(ethoxypolyoxypropyl)ammonium chloride

dimethyl-di(ethoxypolyoxypropyl)ammonium chloride

2,6-dichloro-benzonitrile
1194-65-6

2,6-dichloro-benzonitrile

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With potassium fluoride In 5,5-dimethyl-1,3-cyclohexadiene
trimethyl(ethoxypolyoxypropyl)ammonium chloride

trimethyl(ethoxypolyoxypropyl)ammonium chloride

2,6-dichloro-benzonitrile
1194-65-6

2,6-dichloro-benzonitrile

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With potassium fluoride In 5,5-dimethyl-1,3-cyclohexadiene
3-chloro-2,6-difluorobenzonitrile
86225-73-2

3-chloro-2,6-difluorobenzonitrile

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With sodium hydroxide; palladium-carbon catalyst In water
2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With Dimethylphenylsilane; o-phenylenebis(diphenylphosphine); potassium tert-butylate; copper(l) chloride In tetrahydrofuran for 12h; Inert atmosphere; Reflux; regioselective reaction;100 %Spectr.
2,6-difluorobenzylamine
69385-30-4

2,6-difluorobenzylamine

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With copper(l) iodide; oxygen In dichloromethane at 20℃; under 760.051 Torr; for 6h; Sealed tube;74 %Spectr.
potassiumhexacyanoferrate(II) trihydrate

potassiumhexacyanoferrate(II) trihydrate

C12H3F7O3S

C12H3F7O3S

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In N,N-dimethyl-formamide at 40℃; for 3h; Sealed tube; Green chemistry;
C26H18AuF2N2P

C26H18AuF2N2P

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
In 1,4-dioxane at 65℃; Kinetics; Inert atmosphere; Schlenk technique; Sealed tube;
2,6-dichlorotoluene
118-69-4

2,6-dichlorotoluene

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentachloride; chlorine / 150 °C
2: acetic acid; zinc(II) chloride; hydroxylamine hydrochloride; sodium acetate / 8 h / Reflux
3: potassium fluoride; tetrabutylammomium bromide / 12 h / 170 °C
View Scheme
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

2,6-difluorobenzamide
18063-03-1

2,6-difluorobenzamide

Conditions
ConditionsYield
With water; nitrile hydratase from Rhodococcus rhodochrous J1 at 25℃; for 22h; KH2PO4-K2HPO4 puffer pH=8.0;100%
With dihydrogen peroxide; sodium hydroxide at 50℃; for 5h; Temperature;91.2%
With sulfuric acid at 70℃; for 4h;90%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

sodium methylate
124-41-4

sodium methylate

2-fluoro-6-methoxybenzonitrile
94088-46-7

2-fluoro-6-methoxybenzonitrile

Conditions
ConditionsYield
In methanol at 0 - 20℃;99%
In methanol at 0℃;86%
In methanol at 0 - 20℃;
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

2-amino-6-fluorobenzonitrile
77326-36-4

2-amino-6-fluorobenzonitrile

Conditions
ConditionsYield
With ammonia In dimethyl sulfoxide at 80℃; for 80h; closed bottle;99%
With ammonia In ethanol at 140℃; under 10343.2 Torr; for 6h;97%
With ammonia In dimethyl sulfoxide at 80 - 120℃;97.5%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

2,2-bis(4-hydroxyphenyl)propane bistrimethylsilyl ether
4387-16-0

2,2-bis(4-hydroxyphenyl)propane bistrimethylsilyl ether

polymer; monomer(s): 1,1-bis(4-trimethylsilyloxyphenyl)-1-methylethane; 2,6-difluorobenzonitrile

polymer; monomer(s): 1,1-bis(4-trimethylsilyloxyphenyl)-1-methylethane; 2,6-difluorobenzonitrile

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 140 - 145℃; for 48h;99%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

(+/-)-α-(o-(trifluoromethyl)phenyl)ethyl alcohol
79756-81-3

(+/-)-α-(o-(trifluoromethyl)phenyl)ethyl alcohol

2-fluoro-6-[1-(2-trifluoromethylphenyl)-ethoxy]-benzonitrile
872181-46-9

2-fluoro-6-[1-(2-trifluoromethylphenyl)-ethoxy]-benzonitrile

Conditions
ConditionsYield
Stage #1: (+/-)-α-(o-(trifluoromethyl)phenyl)ethyl alcohol With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 0.75h;
Stage #2: 2,6 difluorobenzonitrile In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 2.33333h;
99%
With sodium hydride In N,N-dimethyl-formamide at 0℃; for 2h;
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

2-fluoro-6-[4-(2-fluorobenzyl)cyclohexylmethoxy]benzonitrile

2-fluoro-6-[4-(2-fluorobenzyl)cyclohexylmethoxy]benzonitrile

Conditions
ConditionsYield
Stage #1: [4-(2-fluorobenzyl)cyclohexyl]methanol With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2.03333h;
Stage #2: 2,6 difluorobenzonitrile In N,N-dimethyl-formamide at 0℃; for 2.01667h;
98%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

ethylamine
75-04-7

ethylamine

2-ethylamino-6-fluorobenzonitrile
119584-72-4

2-ethylamino-6-fluorobenzonitrile

Conditions
ConditionsYield
In dimethyl sulfoxide for 4h; Ambient temperature;97%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

thiophenol
108-98-5

thiophenol

2,6-bis(phenylthio)benzonitrile
1271825-04-7

2,6-bis(phenylthio)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 25℃;97%
4-Octyne
1942-45-6

4-Octyne

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

(Z)-3-(2,6-difluorophenyl)-2-propylhex-2-enenitrile
1453501-01-3

(Z)-3-(2,6-difluorophenyl)-2-propylhex-2-enenitrile

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel (0); triphenylborane; bis[2-(diphenylphosphino)phenyl] ether at 100℃; for 8h; Inert atmosphere; chemoselective reaction;97%
nitromethane
75-52-5

nitromethane

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

(Z)-1-(2,6-difluorophenyl)-2-nitroethen-1-amine

(Z)-1-(2,6-difluorophenyl)-2-nitroethen-1-amine

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene at 85℃; for 0.5h; Aza-Henry Reaction; Molecular sieve;97%
phenoxazine
135-67-1

phenoxazine

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

2,6-di(10H-phenoxazin-10-yl)benzonitrile

2,6-di(10H-phenoxazin-10-yl)benzonitrile

Conditions
ConditionsYield
With sodium ethanolate In N,N-dimethyl-formamide at 70 - 150℃; for 48h;97%
With sodium hydride In hexane; N,N-dimethyl-formamide; mineral oil for 10h; Inert atmosphere;82%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

2-fluorobenzonitrile
394-47-8

2-fluorobenzonitrile

Conditions
ConditionsYield
With 9,10-phenanthrenequinone In N,N-dimethyl-formamide for 8.25h; Electrochemical reaction;95.7%
1,1,1-tris(4-trimethylsilyloxyphenyl)ethane

1,1,1-tris(4-trimethylsilyloxyphenyl)ethane

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

polymer, product of 1,1,1-tris(4-trimethylsilyloxyphenyl)ethane polycondensation with 2,6-difluorobenzonitrile at 140 - 145 deg C for 48 h, monomers feed ratio 1.0:1.1; monomer(s): 1,1,1-tris(4-trimethylsilyloxyphenyl)ethane; 2,6-difluorobenzonitrile

polymer, product of 1,1,1-tris(4-trimethylsilyloxyphenyl)ethane polycondensation with 2,6-difluorobenzonitrile at 140 - 145 deg C for 48 h, monomers feed ratio 1.0:1.1; monomer(s): 1,1,1-tris(4-trimethylsilyloxyphenyl)ethane; 2,6-difluorobenzonitrile

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 140 - 145℃; for 48h;95%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

benzyl alcohol
100-51-6

benzyl alcohol

2-(benzyloxy)-6-fluorobenzonitrile
94088-45-6

2-(benzyloxy)-6-fluorobenzonitrile

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0 - 20℃;95%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

methylmagnesium chloride
676-58-4

methylmagnesium chloride

2,6-difluoroacetophenone
13670-99-0

2,6-difluoroacetophenone

Conditions
ConditionsYield
Stage #1: 2,6 difluorobenzonitrile; methylmagnesium chloride In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene at 20℃; for 20h; Inert atmosphere;
Stage #2: With sulfuric acid In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; water at 50℃;
95%
Stage #1: 2,6 difluorobenzonitrile; methylmagnesium chloride In tetrahydrofuran; toluene at 36 - 40℃; for 5h; Inert atmosphere;
Stage #2: With sulfuric acid; water In tetrahydrofuran; toluene at 27 - 30℃; for 2.5h; Inert atmosphere;
93 %Chromat.
1-methyl-1H-indole-2,3-dione
2058-74-4

1-methyl-1H-indole-2,3-dione

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

dimedone
126-81-8

dimedone

1-fluoro-1',10,10-trimethyl-10,11-dihydro-5H-spiro[indazolo[3,2-b]quinazoline-7,3'-indoline]-2',8(9H)-dione

1-fluoro-1',10,10-trimethyl-10,11-dihydro-5H-spiro[indazolo[3,2-b]quinazoline-7,3'-indoline]-2',8(9H)-dione

Conditions
ConditionsYield
Stage #1: 2,6 difluorobenzonitrile With hydrazine In ethanol at 80℃; for 0.5h; Green chemistry;
Stage #2: 1-methyl-1H-indole-2,3-dione; dimedone With toluene-4-sulfonic acid In ethanol at 80℃; for 4h; Green chemistry;
95%
10H-phenothiazine
92-84-2

10H-phenothiazine

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

C31H19N3S2

C31H19N3S2

Conditions
ConditionsYield
With sodium ethanolate In N,N-dimethyl-formamide at 70 - 150℃; for 48h;95%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

3-amino-4-fluoro-1H-indazole

3-amino-4-fluoro-1H-indazole

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 90℃; for 4h; Inert atmosphere;94%
With hydrazine hydrate In ethanol at 90℃; for 4h; Inert atmosphere;94%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

N-cyclopentyl-3-(hydroxymethyl)-2-oxopiperidine-3-carboxamide

N-cyclopentyl-3-(hydroxymethyl)-2-oxopiperidine-3-carboxamide

3-((2-cyano-3-fluorophenoxy)methyl)-N-cyclopentyl-2-oxopiperidine-3-carboxamide

3-((2-cyano-3-fluorophenoxy)methyl)-N-cyclopentyl-2-oxopiperidine-3-carboxamide

Conditions
ConditionsYield
Stage #1: N-cyclopentyl-3-(hydroxymethyl)-2-oxopiperidine-3-carboxamide With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h; Inert atmosphere;
Stage #2: 2,6 difluorobenzonitrile In tetrahydrofuran; mineral oil at 0 - 20℃; Inert atmosphere;
94%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

indole-2,3-dione
91-56-5

indole-2,3-dione

dimedone
126-81-8

dimedone

1-fluoro-10,10-dimethyl-10,11-dihydro-5H-spiro[indazolo[3,2-b]quinazoline-7,3'-indoline]-2',8(9H)-dione

1-fluoro-10,10-dimethyl-10,11-dihydro-5H-spiro[indazolo[3,2-b]quinazoline-7,3'-indoline]-2',8(9H)-dione

Conditions
ConditionsYield
Stage #1: 2,6 difluorobenzonitrile With hydrazine In ethanol at 80℃; for 0.5h; Green chemistry;
Stage #2: indole-2,3-dione; dimedone With toluene-4-sulfonic acid In ethanol at 80℃; for 4h; Green chemistry;
94%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

3-Trifluoromethylphenol
98-17-9

3-Trifluoromethylphenol

2-fluoro-6-(3-(trifluoromethyl)phenoxy)benzonitrile

2-fluoro-6-(3-(trifluoromethyl)phenoxy)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 16h;93%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

9,9-bis(4-hydroxyphenyl)fluorene
3236-71-3

9,9-bis(4-hydroxyphenyl)fluorene

C135H79F2N5O8

C135H79F2N5O8

Conditions
ConditionsYield
Stage #1: 2,6 difluorobenzonitrile; 9,9-bis(4-hydroxyphenyl)fluorene With potassium carbonate In N,N-dimethyl acetamide; toluene at 140 - 165℃; for 5h; Inert atmosphere; Dean-Stark;
Stage #2: 2,6 difluorobenzonitrile In N,N-dimethyl acetamide; toluene at 160℃; for 1h; Inert atmosphere; Dean-Stark;
92%
5-methoxyisatine
39755-95-8

5-methoxyisatine

2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

dimedone
126-81-8

dimedone

1-fluoro-5'-methoxy-10,10-dimethyl-10,11-dihydro-5H-spiro[indazolo[3,2-b]quinazoline-7,3'-indoline]-2',8(9H)-dione

1-fluoro-5'-methoxy-10,10-dimethyl-10,11-dihydro-5H-spiro[indazolo[3,2-b]quinazoline-7,3'-indoline]-2',8(9H)-dione

Conditions
ConditionsYield
Stage #1: 2,6 difluorobenzonitrile With hydrazine In ethanol at 80℃; for 0.5h; Green chemistry;
Stage #2: 5-methoxyisatine; dimedone With toluene-4-sulfonic acid In ethanol at 80℃; for 4h; Green chemistry;
92%
2,6 difluorobenzonitrile
1897-52-5

2,6 difluorobenzonitrile

guanidine hydrogen carbonate
124-46-9, 20734-13-8, 100224-74-6, 593-85-1

guanidine hydrogen carbonate

2,4-diamino-5-fluoroquinazoline
119584-70-2

2,4-diamino-5-fluoroquinazoline

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 140 - 142℃; for 5h;91%
In N,N-dimethyl acetamide at 140℃; for 8h;77%
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