19100-91-5Relevant articles and documents
12-EPI PLEUROMUTILINS
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Paragraph 0616, (2016/12/01)
A compound selected from 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-sulfanyl)-acetyl]-12-epi-mutilins, or 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-oxy)-acetyl]-12-epi-mutilins, wherein 12-epi-mutilin is characterized in that the mutilin ring at position 12 is substituted by two substituents, the first substituent at position 12 of the mutilin ring is a methyl group which methyl group has the inverse stereochemistry compared with the stereochemistry of the methyl group at position 12 of the naturally occurring pleuromutilin ring, the second substituent at position 12 of the mutilin ring is a hydrocarbon group comprising at least one nitrogen atom and all other substituents of the mutilin ring having the same stereochemistry compared with the stereochemistry of the substituents at the corresponding positions in the naturally occurring pleuromutilin ring; optionally in the form of a salt and/or solvate, wherein the naturally occurring pleuromutilin is of formula processes for the preparation of such compounds and their use as pharmaceuticals.
SYNTHESIS OF ARACHIDONIC ACID METABOLITES PRODUCED BY PURIFIED KIDNEY CORTEX MICROSOMAL CYTOCHROME P-450
Manna, Sukumar,Falck, J. R.,Chacos, N.,Capdevila, J.
, p. 33 - 36 (2007/10/02)
Reported are the synthesis and structure confirmation of the major metabolites produced during the NADPH dependent oxidation of arachidonic acid by a reconstituted enzyme system containing purified kidney cortex microsomal cytochrome P-450.
