1912-44-3

Basic information

• Product Name: 1H-Indole-3-aceticacid,6-chloro-(9CI)
• Synonyms: 1H-Indole-3-aceticacid,6-chloro-(9CI);Nsc295295;6-Chloroindole-3-acetic acid;2-(6-Chloro-1H-indol-3-yl)acetic acid;(6-Chloro-1H-indol-3-yl)-acetic acid;SR 058;1H-Indole-3-aceticacid,6-chloro
• CAS NO: 1912-44-3
• Molecular Formula: C₁₀H₈ClNO₂
• Molecular Weight: 209.631
• Product Categories: INDOLE
• Mol File: 1912-44-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 182-184℃ (decomposition)
• Boiling Point: 445.6°Cat760mmHg
• Flash Point: 223.3°C
• Appearance: /
• Density: 1.483g/cm³
• Vapor Pressure: 1.01E-08mmHg at 25°C
• Refractive Index: 1.698
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.37±0.30(Predicted)
• CAS DataBase Reference: 1H-Indole-3-aceticacid,6-chloro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-aceticacid,6-chloro-(9CI)(1912-44-3)
• EPA Substance Registry System: 1H-Indole-3-aceticacid,6-chloro-(9CI)(1912-44-3)

Safety Data

• Hazardous Substances Data: 1912-44-3(Hazardous Substances Data)

Usage

General Description

1H-Indole-3-acetic acid, 6-chloro- (9CI) is a synthetic auxin, a type of plant hormone that regulates various aspects of plant growth and development. This chemical compound belongs to the class of organic compounds known as indole-3-acetic acid derivatives, which are compounds containing an indole-3-acetic acid moiety (indole ring interconnected with an acetic acid). It is a particular kind of chloroindole, denoting that it contains a chlorine atom. Specific information about its physical properties and safety measures are not widely available, therefore its handling should be done with utmost care, assuming potential hazards.

InChI:InChI=1/C10H8ClNO2/c11-7-1-2-8-6(3-10(13)14)5-12-9(8)4-7/h1-2,4-5,12H,3H2,(H,13,14)

Upstream product

• 17422-33-2 6-chloroindole 
• 107-14-2 chloroacetonitrile 
• 1392273-26-5 (6-chloro-1H-indol-3-yl)acetic acid ethyl ester 
• 929005-85-6 2-oxo-2-(6-chloro-1H-indol-3-yl)acetic acid 
• 61220-58-4 2-(6-chloro-1H-indol-3-yl)acetonitrile 

Downstream Products

• 388574-11-6 6-Chloro-1-methylindole-3-acetic acid 
• 53859-25-9 methyl 2-(6-chloro-1H-indol-3-yl)acetate 
• 1239701-34-8 C₆₈H₈₄ClN₇O₁₃SSi₂ 
• 1334298-80-4 methyl 2-(1-methyl-6-phenyl-indol-3-yl)acetate 
• 1334298-64-4 2-(1-methyl-6-phenyl-1H-indol-3-yl)ethanol 

Relevant articles and documents

Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst

Asymmetric dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeds under mild reaction conditions to provide fluoropyrroloindoline derivatives in a highly enantioselective manner. Various substitution patterns on the indole ring are well tolerated. To facilitate the reaction and ensure reproducibility, the addition of water is essential, and its possible role is discussed.

INDOLECARBOXYLIC ACID DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY

Indolecarboxylic acid derivatives having DP receptor antagonistic activity and pharmaceutical compositions containing the compounds as active ingredients; and further relevant therapeutic agents for allergic diseases. There are provided compounds, their pharmaceutically acceptable salts or solvates thereof, the compounds represented by the general formula: (I) wherein the ring A is an aromatic carbon ring, etc.; the ring B is a nonaromatic-nitrogen-containing heterocycle, etc.; the formula -X1=X2-X3=X4- is the formula -C(R1)=C(R2)-C(R3)=C(R4)-, etc.; X5 is C(R5) or N; each of R1, R2, R3, R4 and R5 independently is a hydrogen atom, a halogen atom, etc.; R6 is the formula -Z-R10 (in which Z is alkylene, etc.; and R10 is carboxyl, etc.), etc.; R7 is an optionally substituted alkyloxy, etc.; each of R8s independently is a halogen atom, etc.; each of R9s independently is an optionally substituted alkyl, etc.; Y is a single bond, etc.; n is 0, etc.; and q is 0, etc.

Use of indole-3-acetic acid derivatives in medicine

Compounds of formula (I), or physiologically functional derivatives thereof, wherein: R1, R2, R3 and R′3 are independently selected from II or lower alkyl; and R4, R5, R6 and R7 are independently selected from H, electron withdrawing groups (such as F, Cl, Br, I, OCF3, carboxyl groups, acetal groups, electron deficient aryl groups), lower alkyl groups lower alkoxy groups, aryl groups or aryloxy groups, wherein it least one of R4, R5, R6, and R7 is selected from an electron withdrawing group, may be used in methods of therapy, particular in treating neoplastic diseases in methods of GDEPT, ADPET, PDEPT and PDT