61220-58-4

Basic information

• Product Name: 6-CHLOROINDOLE-3-ACETONITRILE
• Synonyms: 6-CHLOROINDOLE-3-ACETONITRILE;6-CHLORO-3-INDOLEACETONITRILE;2-(6-Chloro-1H-indol-3-yl)acetonitrile
• CAS NO: 61220-58-4
• Molecular Formula: C10H7ClN2
• Molecular Weight: 190.63
• Product Categories: Aromatic Nitriles
• Mol File: 61220-58-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 103 °C
• Boiling Point: 406.5°C at 760 mmHg
• Flash Point: 199.7°C
• Appearance: /
• Density: 1.361g/cm³
• Vapor Pressure: 8.09E-07mmHg at 25°C
• Refractive Index: 1.679
• Storage Temp.: 2-8°C
• PKA: 15.42±0.30(Predicted)
• CAS DataBase Reference: 6-CHLOROINDOLE-3-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLOROINDOLE-3-ACETONITRILE(61220-58-4)
• EPA Substance Registry System: 6-CHLOROINDOLE-3-ACETONITRILE(61220-58-4)

Safety Data

• Hazardous Substances Data: 61220-58-4(Hazardous Substances Data)

Usage

General Description

6-Chloroindole-3-acetonitrile is a chemical compound that belongs to the group of organic substances known as indoles which are aromatic heterocycles. The chemical formula of this compound is C10H6ClN, and it is often referred to by its systemic name - 2-(6-chloro-1H-indol-3-yl)acetonitrile. The molecular weight of this compound is 197.618. As with many chemicals, it is crucial to handle them carefully, given that improper handling may cause harm. Exact properties such as color, odor, boiling point, and melting point may vary and depend on the specific methods of synthesis. Overall, 6-chloroindole-3-acetonitrile is an important tool in chemical research.

InChI:InChI=1/C10H7ClN2/c11-8-1-2-9-7(3-4-12)6-13-10(9)5-8/h1-2,5-6,13H,3H2

Upstream product

• 50517-12-9 1-(6-chloro-1H-indol-3-yl)-N,N-dimethylmethanamine 
• 77-78-1 dimethyl sulfate 
• 773837-37-9 sodium cyanide 
• 17422-33-2 6-chloroindole 
• 74-88-4 methyl iodide 
• 703-82-2 6-chloro-1H-indole-3-carbaldehyde 

Downstream Products

• 1912-44-3 6-chloroindole-3-acetic acid 
• 3670-19-7 2-(6-chloro-1H-indole-3-yl)ethan-1-amine 

Relevant articles and documents

N-skatyltryptamines-dual 5-ht6r/d2r ligands with antipsychotic and procognitive potential

A series of N-skatyltryptamines was synthesized and their affinities for serotonin and dopamine receptors were determined. Compounds exhibited activity toward 5-HT1A, 5-HT2A, 5-HT6, and D2 receptors. Substitution patterns resulting in affinity/activity switches were identified and studied using homology modeling. Chosen hits were screened to determine their metabolism, permeability, hepatotoxicity, and CYP inhibition. Several D2 receptor antagonists with additional 5-HT6R antagonist and agonist properties were identified. The former combination resembled known antipsychotic agents, while the latter was particularly interesting due to the fact that it has not been studied before. Selective 5-HT6R antagonists have been shown previously to produce procognitive and promnesic effects in several rodent models. Administration of 5-HT6R agonists was more ambiguous-in naive animals, it did not alter memory or produce slight amnesic effects, while in rodent models of memory impairment, they ameliorated the condition just like antagonists. Using the identified hit compounds 15 and 18, we tried to sort out the difference between ligands exhibiting the D2R antagonist function combined with 5-HT6R agonism, and mixed D2/5-HT6R antagonists in murine models of psychosis.

NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES

The present invention relates to a new class of indole derivatives, having a particular MKlp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral infections and lung diseases.