19271-19-3

Basic information

• Product Name: Methyl6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate
• Synonyms: Methyl6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate;6-Fluoro-1,4-dihydro-4-oxo-2-quinolinecarboxylic acid methyl ester;6-Fluoro-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid Methyl ester
• CAS NO: 19271-19-3
• Molecular Formula: C₁₁H₈FNO₃
• Molecular Weight: 221
• Mol File: 19271-19-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 336℃
• Flash Point: 157℃
• Appearance: /
• Density: 1.366
• Vapor Pressure: 0.000119mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Methyl6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate(19271-19-3)
• EPA Substance Registry System: Methyl6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate(19271-19-3)

Safety Data

• Hazardous Substances Data: 19271-19-3(Hazardous Substances Data)

Usage

General Description

Methyl 6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate is a synthetic chemical compound that belongs to the quinolone class of antibiotics. It is commonly used in the synthesis of various pharmaceutical drugs for its antibacterial and antimicrobial properties. The presence of the fluoro and oxo functional groups in its chemical structure contributes to its potent biological activity. Methyl6-fluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate has shown promising results in inhibiting the growth of various bacterial strains and has been extensively studied for its potential therapeutic applications. It is commonly used as a building block in the development of new drugs and has potential to be utilized in the treatment of bacterial infections in the future.

InChI:InChI=1/C11H8FNO3/c1-16-11(15)9-5-10(14)7-4-6(12)2-3-8(7)13-9/h2-5H,1H3,(H,13,14)

Upstream product

• 20866-71-1 (p-fluoroanilino)-fumaric acid, dimethyl ester 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 301823-61-0 4-chloro-6-fluoro-quinoline-2-carboxylic acid methyl ester 
• 530077-39-5 methyl 1-{[(benzoylamino)carbonyl]amino}-6-fluoro-4-oxo-1,4-dihydro-2-quinolinecarboxylate 
• 530077-29-3 methyl 6-fluoro-1-[({[(4-methylphenyl) sulfonyl]amino}carbonyl)amino]-4-oxo-1,4-dihydro-2-quinolinecarboxylate 
• 353290-46-7 1-(2-benzyloxy-ethyl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid 
• 353290-51-4 1-(2-benzyloxy-ethyl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid ethyl ester 
• 301823-80-3 4-ethoxy-6-fluoro-quinoline-2-carboxylic acid 2,4,6-trichloro-phenyl ester 
• 1444310-03-5 6-fluoro-1,4-dihydro-N′-(3-hydroxy-2-cyclohexenylidene)-4-oxoquinoline-2-carbohydrazide 

Relevant articles and documents

Quinolone analogues 12: Synthesis and tautomers of 2-substituted 4-quinolones and related compounds

The 4-quinolone-2-carboxylates 4a,b were converted into the 4-quinolone-2-carbohydrazides 5a,b, hydrazones 6,7,10, and related compounds 8,9,11. The 4-methoxyquinoline-2-carboxylate 12 was also transformed into the 4-methoxyquinoline-2-carbohydrazide 13, which was modified to the hydrazone 14 and related compound 15. The antimicrobial activities of compounds 6b and 14 are described together with the 4-oxo and 4-hydroxy tautomers of compounds 4-11 in deuteriodimethyl sulfoxide and deuteriotrifluoroacetic acid.

2-AMINOCARBONYL-QUINOLINE COMPOUNDS AS PLATELET ADENOSINE DIPHOSPHATE RECEPTOR ANTAGONISTS

Compounds of formula (I), where m, n, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

Synthesis and evaluation of quinoline carboxyguanidines as antidiabetic agents

The synthesis and in vivo activities of a series of substituted quinoline carboxyguanidines as a possible novel class of antidiabetic agents is described. (C) 2000 Elsevier Science Ltd. All rights reserved.