192933-33-8

Basic information

• Product Name: Benzoic acid, 4-[[(5,6-dicyano-3-methylpyrazinyl)methyl]formylamino]-, methyl ester
• CAS NO: 192933-33-8
• Molecular Formula: C17H13N5O3
• Molecular Weight: 335.322
• Mol File: 192933-33-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[(5,6-dicyano-3-methylpyrazinyl)methyl]formylamino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[(5,6-dicyano-3-methylpyrazinyl)methyl]formylamino]-, methyl ester(192933-33-8)
• EPA Substance Registry System: Benzoic acid, 4-[[(5,6-dicyano-3-methylpyrazinyl)methyl]formylamino]-, methyl ester(192933-33-8)

Safety Data

• Hazardous Substances Data: 192933-33-8(Hazardous Substances Data)

Upstream product

• 887577-52-8 2-(N-formyl-p-methoxycarbonylanilino)acetic acid 
• 52197-12-3 5-methylpyrazine-2,3-dicarbonitrile 
• 53405-05-3 N-formyl p-aminobenzoic acid methyl ester 

Downstream Products

• 192933-39-4 4-[(6-Cyano-3-methyl-5-methylamino-pyrazin-2-ylmethyl)-formyl-amino]-benzoic acid methyl ester 

Relevant articles and documents

Synthesis of pteridine derivatives related to folic acid and methanopterin from pyrazine-2,3-dicarbonitrile

Pteridine derivatives related to folic acid and methanopterin were synthesized by two methods. The first synthesis is initiated by the radical substitution of 5-methylpyrazine-2,3-dicarbonitrile (3) with the (N-acyl- anilino)alkyl radical to give 6-methyl-5-(N-acylanilino)alkylpyrazine-2,3- dicarbonitrile (9) and was followed by the substitution of the 2-carbonitrile with methylamine and further conversion to 1 -methyl-2-amino-6-(N- acylanilino)-alkyl-7-methylpteridin-4(1H)-imine 11 by the action of guanidine. The second method is initiated by radical hydroxymethylation of 5- methylpyrazine-2,3-dicarbonitrile (3) to give 5-hydroxymethyl-6- methylpyrazine-2,3-dicarbonitrile (15), followed by oxidation of the hydroxymethyl group, N-phenylimination, and the substitution of the 2- carbonitrile with methylamine to give 6-methyl-2-methyl-amino-5-(N- phenylimino)methenylpyrazine-3-carbonitrile (18). The reduction of the imino group and the final cyclization with guanidine gives 2-amino-6-anilinomethyl- 1,7-dimethylpteridin-4(1H)-imine (20).