52197-12-3

Basic information

• Product Name: 2,3-DICYANO-5-METHYLPYRAZINE
• Synonyms: 2,3-DICYANO-5-METHYLPYRAZINE;5-METHYL-2,3-PYRAZINEDICARBONITRILE;Dicyanomethylpyrazine;5-METHYLPYRAZINE-2,3-DICARBONITRILE;2,3-DICYANO-5-METHYLPYRAZINE 99+%
• CAS NO: 52197-12-3
• Molecular Formula: C₇H₄N₄
• Molecular Weight: 144.13
• Product Categories: Pyrazines, Pyrimidines & Pyridazines;Dicyanopyrazines, etc. (Building Blocks for Phthalonitriles & Naphthalonitriles);Functional Materials;Mono- & Polyalkylpyrazines;Phthalonitriles & Naphthalonitriles;Pyrazines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 52197-12-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 100°C
• Boiling Point: 377.3 °C at 760 mmHg
• Flash Point: 128.3 °C
• Appearance: /
• Density: 1.28 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: -7.00±0.10(Predicted)
• CAS DataBase Reference: 2,3-DICYANO-5-METHYLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DICYANO-5-METHYLPYRAZINE(52197-12-3)
• EPA Substance Registry System: 2,3-DICYANO-5-METHYLPYRAZINE(52197-12-3)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 52197-12-3(Hazardous Substances Data)

Usage

General Description

2,3-DICYANO-5-METHYLPYRAZINE is a chemical compound with the molecular formula C7H4N4. It is a pyrazine derivative with two cyano groups and a methyl group attached to the ring structure. 2,3-DICYANO-5-METHYLPYRAZINE is commonly used as a flavoring agent in the food industry, adding a roasted and nutty flavor to various food products. It is also used in the production of pharmaceuticals and as a building block in organic synthesis. 2,3-DICYANO-5-METHYLPYRAZINE is considered to be relatively stable and non-toxic, making it a versatile and valuable chemical compound for various industrial applications.

Upstream product

• 1187-42-4 diaminomaleonitrile 
• 78-98-8 2-oxopropanal 

Downstream Products

• 5521-60-8 5-methyl-pyrazine-2,3-dicarboxylic acid 
• 192933-53-2 2,3-dicyano-6-hydroxymethyl-5-methylpyrazine 
• 192933-29-2 5-(N-acetylamino)methyl-6-methylpyrazine-2,3-dicarbonitrile 
• 192933-34-9 N-[1-(5,6-Dicyano-3-methyl-pyrazin-2-yl)-ethyl]-N-phenyl-formamide 
• 192933-32-7 N-(5,6-Dicyano-3-methyl-pyrazin-2-ylmethyl)-N-phenyl-formamide 
• 192933-30-5 N-(4-Cyano-phenyl)-N-(5,6-dicyano-3-methyl-pyrazin-2-ylmethyl)-acetamide 
• 192933-33-8 4-[(5,6-Dicyano-3-methyl-pyrazin-2-ylmethyl)-formyl-amino]-benzoic acid methyl ester 
• 192933-55-4 5-(N-phenylimino)methenyl-6-methylpyrazine-2,3-dicarbonitrile 
• 192933-56-5 5-Methyl-3-methylamino-6-[(E)-phenyliminomethyl]-pyrazine-2-carbonitrile 
• 192933-57-6 2-methylamino-5-anilinomethyl-6-methylpyrazine-3-carbonitrile 
• 192933-38-3 N-(6-Cyano-3-methyl-5-methylamino-pyrazin-2-ylmethyl)-N-phenyl-formamide 
• 192933-35-0 N-(6-Cyano-3-methyl-5-methylamino-pyrazin-2-ylmethyl)-N-phenyl-acetamide 
• 192933-40-7 N-[1-(6-Cyano-3-methyl-5-methylamino-pyrazin-2-yl)-ethyl]-N-phenyl-formamide 
• 192933-47-4 N-(6-Cyano-5-ethylamino-3-methyl-pyrazin-2-ylmethyl)-N-phenyl-acetamide 

Relevant articles and documents

Synthesis of pteridine derivatives related to folic acid and methanopterin from pyrazine-2,3-dicarbonitrile

Pteridine derivatives related to folic acid and methanopterin were synthesized by two methods. The first synthesis is initiated by the radical substitution of 5-methylpyrazine-2,3-dicarbonitrile (3) with the (N-acyl- anilino)alkyl radical to give 6-methyl-5-(N-acylanilino)alkylpyrazine-2,3- dicarbonitrile (9) and was followed by the substitution of the 2-carbonitrile with methylamine and further conversion to 1 -methyl-2-amino-6-(N- acylanilino)-alkyl-7-methylpteridin-4(1H)-imine 11 by the action of guanidine. The second method is initiated by radical hydroxymethylation of 5- methylpyrazine-2,3-dicarbonitrile (3) to give 5-hydroxymethyl-6- methylpyrazine-2,3-dicarbonitrile (15), followed by oxidation of the hydroxymethyl group, N-phenylimination, and the substitution of the 2- carbonitrile with methylamine to give 6-methyl-2-methyl-amino-5-(N- phenylimino)methenylpyrazine-3-carbonitrile (18). The reduction of the imino group and the final cyclization with guanidine gives 2-amino-6-anilinomethyl- 1,7-dimethylpteridin-4(1H)-imine (20).