193276-55-0

Basic information

• Product Name: 3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one
• Synonyms: 3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one
• CAS NO: 193276-55-0
• Molecular Weight: 401.485
• Mol File: 193276-55-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one(193276-55-0)
• EPA Substance Registry System: 3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one(193276-55-0)

Safety Data

• Hazardous Substances Data: 193276-55-0(Hazardous Substances Data)

Upstream product

• 213771-69-8 5-bromo-3-[2-(3-bromo-5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide 

Downstream Products

• 272107-22-9 8-chloro-3,10-dibromo-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine 
• 193275-84-2 lonafarnib 
• 193276-49-2 (R)-(+)-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-yl)-1-piperidine 

Relevant articles and documents

An anion-induced regio- and chemoselective acylation and its application to the synthesis of an anticancer agent

Figure presented An efficient Grignard- and organolithium-induced regio- and chemoselective anionic acylation is reported. A number of tricyclic ketones are prepared in good to excellent yields via this method. This method is complementary to the Frieldel-Crafts acylation for electron-deficient substrates. A novel anisole-based Grignard reagent was developed to effect the cyclization of sterically hindered substrates. This novel reagent has been successfully applied to the synthesis of Sch 66336, a candidate for oncologic treatment.