272107-22-9 Usage
Description
8-chloro-3,10-dibromo-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin is a complex organic compound with a unique chemical structure. It is characterized by the presence of a benzo[5,6]cycloheptal[1,2-b]pyridine core, which is substituted with a chlorine atom at the 8th position and two bromine atoms at the 3rd and 10th positions. 8-chloro-3,10-dibromo-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin is of interest due to its potential applications in various fields, particularly in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
8-chloro-3,10-dibromo-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin is used as an intermediate in the synthetic preparation of lonafarnib, a potential anticancer agent. Lonafarnib is a farnesyltransferase inhibitor that targets the Ras protein, which plays a crucial role in cell growth and division. By inhibiting this protein, lonafarnib can help slow down the growth of cancer cells and potentially treat various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 272107-22-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,2,1,0 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 272107-22:
(8*2)+(7*7)+(6*2)+(5*1)+(4*0)+(3*7)+(2*2)+(1*2)=109
109 % 10 = 9
So 272107-22-9 is a valid CAS Registry Number.
272107-22-9Relevant articles and documents
A novel iodide-catalyzed reduction of nitroarenes and aryl ketones with H3PO2 or H3PO3: Its application to the synthesis of a potential anticancer agent
Wu, George G.,Chen, Frank X.,LaFrance, Danny,Liu, Zhijian,Greene, Scott G.,Wong, Yee-Shing,Xie, Ji
supporting information; experimental part, p. 5220 - 5223 (2011/12/04)
A novel iodide-catalyzed reduction method using hypophosphorous and/or phosphorus acids was developed to reduce both diaryl ketones and nitroarenes chemoselectively in the presence of chloro and bromo substituents in high yield. This efficient and practical method has been successfully applied to a large scale production of a potential anticancer agent
A novel enantioselective alkylation and its application to the synthesis of an anticancer agent
Kuo, Shen-Chun,Chen, Frank,Hou, Donald,Kim-Meade, Agnes,Bernard, Charles,Liu, Jinchu,Levy, Stacy,Wu, George G.
, p. 4984 - 4987 (2007/10/03)
A novel enantioselective alkylation of double benzylic substrates with secondary electrophiles is reported. A simple norephedrine-based chiral ligand was synthesized that gives alkylation product in 95% yield and 95% ee. A unique water effect on the enantioselectivity was unveiled. Good to excellent ee values were obtained with a number of double benzylic substrates and secondary electrophiles. This novel reaction has been applied to the synthesis of a promising anticancer agent.