193276-76-5Relevant articles and documents
A novel enantioselective alkylation and its application to the synthesis of an anticancer agent
Kuo, Shen-Chun,Chen, Frank,Hou, Donald,Kim-Meade, Agnes,Bernard, Charles,Liu, Jinchu,Levy, Stacy,Wu, George G.
, p. 4984 - 4987 (2003)
A novel enantioselective alkylation of double benzylic substrates with secondary electrophiles is reported. A simple norephedrine-based chiral ligand was synthesized that gives alkylation product in 95% yield and 95% ee. A unique water effect on the enantioselectivity was unveiled. Good to excellent ee values were obtained with a number of double benzylic substrates and secondary electrophiles. This novel reaction has been applied to the synthesis of a promising anticancer agent.