195983-60-9 Usage
Description
8-CHLORO-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE is a benzodiazepine derivative with a molecular formula of C16H10ClN3O2. It is a psychoactive compound known for its sedative and anxiolytic properties, acting on the central nervous system to enhance the inhibitory effects of the neurotransmitter gamma-aminobutyric acid (GABA), resulting in a calming and relaxing effect. However, it is also recognized for its potential for addiction and dependence.
Uses
Used in Pharmaceutical Industry:
8-CHLORO-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE is used as a sedative and anxiolytic agent for the treatment of anxiety disorders, insomnia, and other conditions that require a calming effect on the central nervous system. Its mechanism of action involves the enhancement of GABAergic neurotransmission, which leads to the desired therapeutic outcomes.
Used in Research Applications:
In the scientific community, 8-CHLORO-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE serves as a research tool for studying the effects of benzodiazepines on the central nervous system and their potential for abuse and dependence. It aids in understanding the molecular mechanisms underlying the anxiolytic and sedative effects of this class of drugs.
Used in Drug Abuse Prevention and Education:
8-CHLORO-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE is also utilized in educational and preventive programs to raise awareness about the risks associated with benzodiazepine abuse and dependence, emphasizing the importance of responsible use and the need for proper medical supervision when using these medications.
Check Digit Verification of cas no
The CAS Registry Mumber 195983-60-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,5,9,8 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 195983-60:
(8*1)+(7*9)+(6*5)+(5*9)+(4*8)+(3*3)+(2*6)+(1*0)=199
199 % 10 = 9
So 195983-60-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H7ClN2O2/c10-5-1-2-6-7(3-5)12-8(13)4-11-9(6)14/h1-3H,4H2,(H,11,14)(H,12,13)
195983-60-9Relevant articles and documents
Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase
Ding, Charles Z.,Batorsky, Roberta,Bhide, Rajeev,Chao, Hannguang J.,Cho, Young,Chong, Saeho,Gullo-Brown, Johnni,Guo, Peng,Kim, Soong Hoon,Lee, Frank,Leftheris, Katerina,Miller, Arthur,Mitt, Toomas,Patel, Manorama,Penhallow, Becky A.,Ricca, Carol,Rose, William C.,Schmidt, Robert,Slusarchyk, William A.,Vite, Gregory,Yan, Ning,Manne, Veeraswamy,Hunt, John T.
, p. 5241 - 5253 (2007/10/03)
2,3,4,5-Tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepines were found to be potent inhibitors of farnesyltransferase (FT). A hydrophobic substituent at the 4-position of the benzodiazepine, linked via a hydrogen bond acceptor, was important to enzyme i
