19672-59-4

Basic information

• Product Name: 4,4'-Dichlorochalcone
• Synonyms: TRANS-4,4'-DICHLOROCHALCONE;4,4'-DICHLOROCHALCONE;AKOS 94381;1,3-BIS(4-CHLOROPHENYL)PROP-2-EN-1-ONE;4,4''-DICHLOROCHALCONE 98+%;4-Chlorostyryl 4-chlorophenyl ketone;4'-Chloro-β-(4-chlorophenyl)acrylophenone
• CAS NO: 19672-59-4
• Molecular Formula: C₁₅H₁₀Cl₂O
• Molecular Weight: 277.15
• EINECS: -0
• Product Categories: Chalcones
• Mol File: 19672-59-4.mol
• Article Data: 123

Chemical Properties

• Melting Point: 157-159°C
• Boiling Point: 420.1 °C at 760 mmHg
• Flash Point: 177.4 °C
• Appearance: /
• Density: 1.296 g/cm³
• BRN: 2331589
• CAS DataBase Reference: 4,4'-Dichlorochalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-Dichlorochalcone(19672-59-4)
• EPA Substance Registry System: 4,4'-Dichlorochalcone(19672-59-4)

Safety Data

• RTECS: UD5572635
• Hazardous Substances Data: 19672-59-4(Hazardous Substances Data)

Usage

General Description

4,4'-Dichlorochalcone is a synthetic compound that belongs to the chalcone family of chemicals. As a dichlorinated derivative of chalcone, it features two chlorine atoms, each attached on both rings of the chalcone structure in the 4,4' positions. Its molecular formula is C15H10Cl2O. Chalcones, including 4,4'-Dichlorochalcone, are known for their wide range of biological activities. This includes their potential in pharmaceutical applications, especially for their anti-inflammatory, antifungal, antitumor, and anti-malarial properties. It’s essential to note that, as with most compounds with biological activity, the exact effects and safety levels of 4,4'-Dichlorochalcone can vary greatly depending on the specific context of its usage, thus requiring extensive research and testing.

Upstream product

• 64-17-5 ethanol 
• 104-88-1 4-chlorobenzaldehyde 
• 99-91-2 para-chloroacetophenone 
• 64-19-7 acetic acid 
• 122-00-9 para-methylacetophenone 
• 87275-63-6 2,3-dibromo-1,3-di(4-chlorophenyl)-1-propanone 
• 57-13-6 urea 
• 58949-81-8 1,3-Bis-(4-chloro-phenyl)-3-hydroxy-propan-1-one 
• 7647-01-0 hydrogenchloride 
• 7664-93-9 sulfuric acid 
• 86980-61-2 N-[1,3-bis-(4-chloro-phenyl)-allyliden]-p-anisidine 
• 19339-59-4 1-(4-chloro-phenyl)-2-thiocyanato-ethanone 
• 13677-54-8 1,3-bis(4-chlorophenyl)prop-2-en-1-ol 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 87275-63-6 2,3-dibromo-1,3-di(4-chlorophenyl)-1-propanone 
• 50800-82-3 3,5-bis-(4-chloro-phenyl)-4,5-dihydro-1H-pyrazole 
• 97009-36-4 1,3-Bis(4-chlorophenyl)-1-propanone 
• 20725-23-9 (2RS,3SR)-2,3-dichloro-1,3-bis-(4-chloro-phenyl)-propan-1-one 
• 20725-23-9 (2RS,3RS)-2,3-dichloro-1,3-bis-(4-chloro-phenyl)-propan-1-one 
• 13677-54-8 (+/-)-1,3t-bis-(4-chloro-phenyl)-allyl alcohol 
• 725-86-0 rac-trans-1,2-bis(4-chlorophenyl)cyclopropane 
• 57845-06-4 3-(4-chlorophenyl)-5-(4-chlorophenyl)-1-phenyl-2-pyrazoline 
• 55902-31-3 (E)-1,3-Bis-(4-chloro-phenyl)-2-nitro-propenone 
• 108325-93-5 3-(4-chlorobenzoyl)-4-(4-chlorophenyl)-4,5-dihydropyrazole 
• 118757-39-4 5,7-Bis-(4-chloro-phenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine 
• 111336-89-1 5,7-Bis-(4-chloro-phenyl)-3-methyl-1-phenyl-1,6,7,8-tetrahydro-pyrazolo[3,4-b][1,4]diazepine 
• 128917-87-3 4,6-bis(4-chlorophenyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 128883-51-2 4,6-di-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro-3-pyridinecarboxamide 

Relevant articles and documents

Solution phase combinatorial synthesis and screening of mini libraries of arylchalcones for antibacterial activity

The solution-phase combinatorial synthesis of aryl chalcones was studied by synthesizing a 6x4 array mini library. The mini libraries of chalcones were synthesized by condensation of 4-substituted acetophenones and various aryl/heteroaryl carbaldehydes. A

Stereo-controlled deamination of ketoaziridines using Ph3P, I2

Ph3P, I2is an efficient reagent for the stereo-controlled deamination of non-activated aziridines, N-H and N-alkyl aziridines, using. The method works gives the corresponding trans-alkenes from both cis and trans-aziridines. A plausible mechanism is proposed for the ring opening and deamination of keto-aziridines in the presence of Ph3P, I2.

Synthesis of chalcone derivatives by phthalhydrazide-functionalized tio2-coated nano-fe3o4 as a new heterogeneous catalyst

Phthalhydrazide immobilized on TiO2-coated nano Fe3O4 (Fe3O4-P) was synthesized and characterized by FT-IR, XRD, SEM, EDS and VSM analysis. The resulting magnetic nanocatalyst was used as a catalyst for the synthesis of chalcone derivatives which affords the desired products in good to excellent yields. This catalyst can be isolated readily after completion of the reaction by an external magnetite field and reused several times without significant loss of activity.

New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity

Nicotinic acid hydrazide was incorporated into new 4,5-dihydro-5-hydroxy-3,5-diphenylpyrazol-1-yl derivatives. Compounds 6a–h were synthesized, and their antihyperlipidemic activity was evaluated in high cholesterol diet-fed rat model. Compounds 6e, 6f were found to decrease the levels of serum total cholesterol by 14–19% compared to control group. Total triglycerides were also reduced by 24–28% and LDL cholesterol by 16%. As expected from parent niacin, compounds 6e and 6f caused an elevation of HDL cholesterol by 33–41%. Docking study supported the ability of designed compounds to block NPC1L1 active site in a manner similar to that observed with ezetimibe.