1985607-83-7

Basic information

• Product Name: Zofluza intermediate
• Synonyms: Zofluza intermediate;CPD1605;7,8-difluoro-6,11-dihydro-Dibenzo[b,e]thiepin-11-ol
• CAS NO: 1985607-83-7
• Molecular Formula: C14H10F2OS
• Molecular Weight: 264.29
• EINECS: -0
• Mol File: 1985607-83-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 379.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.400±0.06 g/cm3(Predicted)
• PKA: 12.57±0.20(Predicted)
• CAS DataBase Reference: Zofluza intermediate(CAS DataBase Reference)
• NIST Chemistry Reference: Zofluza intermediate(1985607-83-7)
• EPA Substance Registry System: Zofluza intermediate(1985607-83-7)

Safety Data

• Hazardous Substances Data: 1985607-83-7(Hazardous Substances Data)

Usage

General Description

Zofluza intermediate refers to an intermediate substance used in the preparation of Zofluza, a prescription medicine used to treat influenza in individuals above the age of 12. Zofluza (otherwise known as Baloxavir Marboxil) works by inhibiting the replication of the influenza virus within the body, thereby easing symptoms and reducing the duration of the illness. The exact chemical structure or process involving the Zofluza intermediate isn't publicly disclosed due to the proprietary nature of pharmaceutical manufacturing. Like many pharmaceutical intermediates, they are valuable for fine-tuning chemical reactions to produce the final active pharmaceutical ingredient (API).

Upstream product

• 455-86-7 3,4-Difluorobenzoic acid 
• 2136287-65-3 3,4-difluoro-2-((phenylthio)methyl)benzoic acid 
• 2136287-66-4 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one 
• 930-69-8 sodium thiophenolate 
• 882-33-7 diphenyldisulfane 
• 130286-84-9 N,N-diethyl-3,4-difluorobenzamide 
• 847502-83-4 3,4-difluoro-2-methylbenzonitrile 
• 847502-81-2 1-bromo-3,4-difluoro-2-methyl-benzene 
• 3828-49-7 1,2-difluoro-3-methyl-benzene 
• 160775-14-4 3,4-difluoro-2-methylbenzoic acid methyl ester 
• 108-98-5 thiophenol 
• 651326-72-6 (6-bromo-2,3-difluorophenyl)methanol 
• 1807193-48-1 1-bromo-2-(bromomethyl)-3,4-difluorobenzene 
• 157652-31-8 3,4-difluoro-2-methyl benzoic acid 

Downstream Products

• 1985605-59-1 (R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione 

Relevant articles and documents

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Synthesis method of baloxavir marboxil intermediate

The invention discloses a synthesis method of a baloxavir marboxil intermediate. The synthesis method comprises the following steps of: taking 7,8-difluorodibenzo[B,E]thiophene-11(6H)-ketone as a raw material, adopting chloro(R,R)-N-(tosyl)-1,2-diphenyl ethylene diamine(chloro)(p-propyl toluene) ruthenium (II) or chloro(S,S)-N-(tosyl)-1,2-diphenyl ethylene diamine(chloro)(p-propyl toluene) ruthenium (II) as a catalyst, reducing carbonyl into chiral alcohol so as to obtain an intermediate namely chiral 7,8-difluoro-dihydrodibenzo[b,e]thiepin-11-ol for synthesizing baloxavir marboxil. The optical purity of baloxavir marboxil synthesized from the intermediate is 98.0% or more, the subsequent purification processes are reduced, the yield is increased, the cost is reduced, and the synthesis method is more suitable for commercial production.