2136287-66-4

Basic information

• Product Name: 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one
• CAS NO: 2136287-66-4
• Molecular Weight: 262.28
• Mol File: 2136287-66-4.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 427.7±45.0 °C(Predicted)
• Density: 1.393±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one(2136287-66-4)
• EPA Substance Registry System: 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one(2136287-66-4)

Safety Data

• Hazardous Substances Data: 2136287-66-4(Hazardous Substances Data)

Usage

General Description

7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one is a chemical compound categorized under the class of dibenzothiazepines, more specifically a dibenzothiazepin-11-one that bears two fluoro substituents at positions 7 and 8. Information on the specific applications, properties, or usage of this particular compound in industries or research may not be readily available as this appears to be a more obscure or less-studied compound. However, thiazepines and their derivatives are generally known for their potential pharmacological activities, particularly in the realm of neuropsychiatric treatments. As with any chemical substance, usage and handling should be done with the appropriate precautions and understanding of its properties.

Upstream product

• 20877-02-5 2-thio-N,N-dimethylbenzamide 
• 1807193-48-1 1-bromo-2-(bromomethyl)-3,4-difluorobenzene 
• 394-35-4 methyl 2-fluorobenzoate 
• 75853-18-8 (2,3-difluoro-phenyl)-methanol 
• 2646-91-5 2,3-difluorobenzaldehyde 
• 367-11-3 ortho-difluorobenzene 
• 446-57-1 1-(chloromethyl)-2,3-difluorobenzene 
• 147-93-3 Thiosalicylic acid 
• 157652-31-8 3,4-difluoro-2-methyl benzoic acid 

Downstream Products

• 1985607-83-7 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepine-11-ol 
• 1985605-59-1 (R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione 
• 1985607-83-7 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepine-11-ol 
• 1985607-83-7 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepine-11-ol 

Relevant articles and documents

Method for synthesizing heterocyclic compound

The invention relates to a synthetic method of a heterocyclic compound, and belongs to the field of pharmaceutical chemistry. The heterocyclic compound can be synthesized by Grignard reaction of a raw material followed by condensation, and the obtained pr

Dibenzo seven-membered ring derivative as well as preparation method and application thereof

The invention relates to a dibenzo seven-membered ring derivative as well as a preparation method and application thereof. The chemical structure of the dibenzo seven-membered ring derivative is shownas a formula (I), and X1 and X2 are respectively and independently selected from H, F, Cl, Br or I. The preparation method has easily available raw materials, and can ensure continuous supply and production; the raw materials are cheap and have the cost advantage; and thiophenol or sodium thiophenol is not used, so that the method is more environment-friendly and is also beneficial to the body health of related personnel. 7,8-difluorodibenzo[b,e]thiazepine-11(6H)-one as one of the products can further react to obtain 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol, and the 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol can be used as an important intermediate for preparing a drug baloxavir, so that baloxavir preparation cost is reduced.

Compound for preparing baloxavir or derivatives thereof as well as preparation method and application of compound

The invention relates to a preparation method of a compound shown as a formula VIII for preparing baloxavir or derivatives thereof, a compound shown as a formula I for preparing the compound shown asthe formula VIII and a preparation method of the compound shown as the formula I. The compound shown as the formula I is used for preparing the compound shown as the formula VIII, the baloxavir or thederivative thereof. The preparation method is simple and convenient to operate, and the raw materials are easily available and low in cost; reaction conditions are mild, and the method is safe and environment-friendly; side reactions are few, and the product purity is high; and the quality is controllable, and the method is suitable for industrial production.