20098-20-8Relevant articles and documents
Adamantane sulfone and sulfonamide 11-β-HSD1 Inhibitors
Sorensen, Bryan,Winn, Martin,Rohde, Jeff,Shuai, Qi,Wang, Jiahong,Fung, Steven,Monzon, Katina,Chiou, William,Stolarik, DeAnne,Imade, Hovis,Pan, Liping,Deng, Xiaoqing,Chovan, Linda,Longenecker, Kenton,Judge, Russell,Qin, Wenying,Brune, Michael,Camp, Heidi,Frevert, Ernst U.,Jacobson, Peer,Link
, p. 527 - 532 (2007)
Potent and selective adamantane sulfone and sulfonamide inhibitors of 11-β-HSD-1 have been discovered. Selected compounds from these series have robust pharmacokinetic profiles and strongly inhibit liver, fat, and brain HSD1 for extended periods after ora
Structure-reactivity relationships: reactions of a 5-substituted aziadamantane in a resorcin[4]arene-based cavitand
Wagner, Gerald,Knoll, Wolfgang,Bobek, Michael M.,Brecker, Lothar,Van Herwijnen, Hendrikus W. G.,Brinker, Udo H.
supporting information; experimental part, p. 332 - 335 (2010/03/25)
(Figure presented) The complexatlon properties of two novel C5-substituted adamantanediazirines within the resorcin[4]arene-based cavitand 4 were investigated In DMSO-d6, revealing that binding Is up to 1.4 kcal/mol stronger for halogenated adamantanediazirines when compared with the unsubstituted species. The thermal behavior of 5-bromo-2-aziadamantane (3) was investigated by DSC analysis as the first representative of the adamantanediazirine family In the neat solid state, as well as encapsulated within the aromatic cavity of cavitand 4. In the solid phase, the reactions of photolytically or thermolytically generated 5-bromo-2-adamantanylldene (11) can be controlled by complexation within cavitand 4.
Reversal of diastereoselectivities in intra- and intermolecular reactions of 2-adamantanylidenes primarily caused by electron-donating and electron-withdrawing substituents on C5
Knoll, Wolfgang,Bobek, Michael M.,Kalchhauser, Hermann,Rosenberg, Murray G.,Brinker, Udo H.
, p. 2943 - 2946 (2007/10/03)
(Matrix presented) A reversal of diastereoselectivity was observed for novel 5-(trimethylsilyl)adamantan-2-ylidene (1c) with regard to 5-hydroxyadamantan-2-ylidene (1a). Ostensibly in intermolecular reactions, 5-substituted 2-adamantanylidenes (1) are ste