38584-33-7Relevant articles and documents
Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors
Plewe, Michael B.,Sokolova, Nadezda V.,Gantla, Vidyasagar Reddy,Brown, Eric R.,Naik, Shibani,Fetsko, Alexandra,Lorimer, Donald D.,Lorimer, Donald D.,Dranow, David M.,Dranow, David M.,Smutney, Hayden,Smutney, Hayden,Bullen, Jameson,Bullen, Jameson,Sidhu, Rana,Sidhu, Rana,Master, Arshil,Master, Arshil,Wang, Junru,Wang, Junru,Kallel, E. Adam,Zhang, Lihong,Kalveram, Birte,Freiberg, Alexander N.,Henkel, Greg,McCormack, Ken
supporting information, p. 1160 - 1167 (2020/05/14)
We identified and explored the structure-activity-relationship (SAR) of an adamantane carboxamide chemical series of Ebola virus (EBOV) inhibitors. Selected analogs exhibited half-maximal inhibitory concentrations (EC50 values) of ～10-15 nM in vesicular s
Ring-fused compound, pharmaceutical composition containing same and application of compound
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Paragraph 0244-0246, (2018/04/01)
The invention discloses a ring-fused compound, a preparation method thereof, pharmaceutical composition containing the compound and an application of the compound. A polycyclic compound (I) as well asan isomer, a prodrug, a stable isotopic derivative or pharmacologically acceptable salt of the compound (I) has the following structure. The polycyclic compound has good IDO1 and/or TDO2 inhibition functions, can effectively treat, relieve and/or prevent various diseases which are related with IDO1 and/or TDO2, such as cancer, virus infection, autoimmune diseases or the like.
ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION
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Page/Page column 90; 91, (2017/09/02)
Compounds of structural Formula (I) were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus.
