202189-77-3

Basic information

• Product Name: 2-(2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,4-dimethyl-4,5-dihydrooxazole
• Synonyms: 2-(2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,4-dimethyl-4,5-dihydrooxazole;2-(1-(4-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-y l)propan-2-yl)phenethyl)piperidin-4-yl)-1-(2-e thoxyethyl)-1H-benzo[d]imidazole
• CAS NO: 202189-77-3
• Molecular Weight: 516.727
• EINECS: -0
• Mol File: 202189-77-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,4-dimethyl-4,5-dihydrooxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,4-dimethyl-4,5-dihydrooxazole(202189-77-3)
• EPA Substance Registry System: 2-(2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,4-dimethyl-4,5-dihydrooxazole(202189-77-3)

Safety Data

• Hazardous Substances Data: 202189-77-3(Hazardous Substances Data)

Usage

General Description

The chemical "2-(2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,4-dimethyl-4,5-dihydrooxazole" is a complex compound with a long and intricate molecular structure. It contains a benzimidazole ring, a piperidine ring, and an oxazole ring, along with ethoxyethyl and propan-2-yl side chains. It also has multiple methyl groups attached to the oxazole ring. This chemical may have potential pharmaceutical or industrial applications due to its complex structure and the presence of various functional groups, but further research is likely needed to fully understand its properties and potential uses.

Upstream product

• 202189-76-2 2-{4-[1-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-1-methylethyl]phenyl}ethyl p-toluenesulfonate 
• 1841081-72-8 1-(2-ethoxyethyl)-2-piperidin-4-yl-1H-benzimidazole hydrochloride 
• 38385-95-4 2-(4-piperidinyl)-1H-benzimidazole 
• 1841081-72-8 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole dihydrochloride 
• 953071-73-3 tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate 
• 17178-11-9 2-ethoxyethyl p-toluenesulfonate 
• 361382-26-5 2-{1-[4-(2-hydroxyethyl)phenyl]-1-methylethyl}-4,5-2H-4,4-dimethyl-oxazole 

Downstream Products

• 202189-78-4 Bilastine 

Relevant articles and documents

Identification and synthesis of potential impurities of bilastine drug substance

Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine. Herein, we describe the synthesis of four new potential impurities of bilastine, namely 2-[4-(2-(4-(1-(2-methoxyethyl)benzimidazole-2-yl) piperidine-1-yl)ethyl) phenyl]-2-methylpropanoic acid (2) (methoxyethyl bilastine), 2-[4-(2-(4-(1-(2-(2-ethoxyethoxy)ethyl)benzimidazole-2-yl) piperidine-1-yl)ethyl)phenyl]-2-methyl propanoic acid (3) ((2-ethoxyethoxy)ethyl bilastine), 2-amino-2-methylpropyl 2-[4-(2-(4-(1-(2-ethoxyethyl)benzimidazole-2-yl) piperidine-1-yl)ethyl)phenyl]-2-methyl propanoate (4) (2-amino-2-methylpropyl ester of bilastine or bilastine open-ring ester) and 2-[4-(2-(4-(1-(2-ethoxyethyl)benzimidazole-2-yl] piperidine-1-yl) ethyl) phenyl]-N-(1-hydroxy-2-methylpropan-2-yl)-2-methylpropanamide (5) [N-(1-hydroxy-2-methyl-2-propanyl)amide of bilastine or bilastine open-ring amide]. Each (2, 3, 4 and 5) is an observed process-related impurity with a possible significant impact on the quality of the drug product. This work is useful for generic pharmaceutical industry for making impurity reference standards. Pharmacopeia is not available for bilastine; hence, the control of these impurities in the API below the threshold level is essential as per International Conference on Harmonization (ICH) recommendations.

A process for the preparation of the compared to the russ sandbank method (by machine translation)

The invention relates to a process for the preparation method compared to the russ sandbank, including I [...] compound added to the water, to add a phase transfer catalyst, paratoluene sulfonyl chloride and sodium hydroxide, after stirring and reacting and filtration to obtain [...] sulfonic acid ester. The sulfonic acid ester added to the water, by adding 2 - (4 - piperidinyl) 1 - H - benzimidazole and phase-transfer catalyst, adding sodium carbonate or potassium carbonate, heating suspension reaction 3 - 5 hours, filtering the obtained intermediate II is added to the strong polar non-protic solvent, by adding sodium hydroxide, phase-transfer catalyst, ethylene glycol is added to the toluene sulfonic acid ester, - 20 - 60° stirring reaction after the end of the filter and wash the obtained intermediate III. The intermediate III into the organic acid aqueous solution, refluxing 3 - 5 hours, water addition, adding alkali saturated, solution reflux 3 - 5 hours, generated in the saturated [...] does not dissolve in the alkaline solution, extraction [...]. The method of mild reaction conditions, the operation is simple, environmental protection, high yield, is suitable for industrial production. (by machine translation)