953071-73-3

Basic information

• Product Name: tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate;Bilastine Impurity 1;tert-Butyl 4-(1H-benzimidazol-2-yl)piperidine-1-carboxylate;2-Methyl-2-propanyl 4-(1H-benzimidazol-2-yl)-1-piperidinecarboxylate
• CAS NO: 953071-73-3
• Molecular Formula: C₁₇H₂₃N₃O₂
• Molecular Weight: 301.38342
• Product Categories: API;Piperidine, heterocyclic
• Mol File: 953071-73-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 497.1±38.0 °C(Predicted)
• Appearance: /
• Density: 1.184±0.06 g/cm3(Predicted)
• PKA: 11.83±0.10(Predicted)
• CAS DataBase Reference: tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate(953071-73-3)
• EPA Substance Registry System: tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate(953071-73-3)

Safety Data

• Hazardous Substances Data: 953071-73-3(Hazardous Substances Data)

Usage

General Description

Tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate is a synthetic chemical compound with a molecular structure consisting of a piperidine ring attached to a benzo[d]imidazole group and a tert-butyl ester. It is commonly used in medicinal chemistry as a building block for the synthesis of potential therapeutic agents. tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate is also used as a research tool to investigate the biological activity and pharmacological properties of its derivatives. Its unique structure and functional groups make it a valuable precursor for the development of new drugs targeting various medical conditions.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 38385-95-4 2-(4-piperidinyl)-1H-benzimidazole 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 95-54-5 1,2-diamino-benzene 
• 498-94-2 isonipecotic acid 
• 88-74-4 2-nitro-aniline 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 

Downstream Products

• 1181267-36-6 tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate 
• 38385-95-4 2-(4-piperidinyl)-1H-benzimidazole 
• 1181267-38-8 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester 
• 202189-78-4 Bilastine 
• 110963-63-8 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole 
• 1381841-42-4 C₁₉H₂₀ClN₃ 

Relevant articles and documents

TITLE: PROCESS FOR THE PREPARATION OF BILASTINE

The present invention relates to a process for the preparation of bilastine, a compound of formula I. The present invention relates to p-xylene solvate of bilastine and process for its preparation. The present invention relates to a process for the prepar

Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow

Cheap and readily available aqueous formaldehyde was used as a formylating reagent in a homologation reaction with nonstabilized diazo compounds, enabled by UV photolysis of bench-stable oxadiazolines in a flow photoreactor. Various aliphatic aldehydes were synthesized along with the corresponding derivatized alcohols and benzimidazoles. No transition-metal catalyst or additive was required to affect the reaction, which proceeded at room temperature in 80 min.

Bilastine preparation method

The invention discloses a Bilastine preparation method. The Bilastine preparation method includes that 2-nitroaniline which is low in price and easy to obtain is taken as a raw material which is subjected to reduction-n-cyclohexylmaleimide reaction, alkyl