1181267-36-6

Basic information

• Product Name: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate;Bilastine Impurity 2;4-[1-(2-Ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;N-Boc 1-(2-Ethyoxyethyl)-2-(4-piperidinyl)-1H-benzimidazole;4-[1-(2-Ethoxy-ethyl)-1H-benzoimidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1181267-36-6
• Molecular Formula: C₂₁H₃₁N₃O₃
• Molecular Weight: 373.48914
• Mol File: 1181267-36-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 521.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 5.31±0.10(Predicted)
• CAS DataBase Reference: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate(1181267-36-6)
• EPA Substance Registry System: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate(1181267-36-6)

Safety Data

• Hazardous Substances Data: 1181267-36-6(Hazardous Substances Data)

Usage

Description

tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate is a complex organic compound with a molecular structure that features a benzimidazole core, a piperidine ring, and a carboxylate group. It is characterized by its potential pharmaceutical applications and is known to be an impurity in the synthesis of certain drugs.

Uses

Used in Pharmaceutical Industry:
tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate is used as an impurity in the synthesis of Bilastine (B385000), a novel, nonsedating H1-antihistamine. It is utilized for the symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria due to its effectiveness in alleviating allergy symptoms without causing drowsiness.
As an impurity, it is essential to monitor and control the levels of tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate in the final drug product to ensure safety, efficacy, and quality. The compound may also be of interest for further research into its potential therapeutic applications or as a starting material for the development of new drugs with similar pharmacological properties.

Upstream product

• 98139-68-5 2-Ethoxyethyl methanesulphonate 
• 953071-73-3 tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate 
• 628-34-2 2-chloroethyl ethyl ether 
• 24424-99-5 di-tert-butyl dicarbonate 
• 38385-95-4 2-(4-piperidinyl)-1H-benzimidazole 
• 95-54-5 1,2-diamino-benzene 
• 498-94-2 isonipecotic acid 
• 88-74-4 2-nitro-aniline 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 592-55-2 2-Bromoethyl ethyl ether 

Downstream Products

• 110963-63-8 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole 
• 1181267-38-8 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester 
• 202189-78-4 Bilastine 

Relevant articles and documents

Preparation method of bilastine important intermediate

According to the preparation method disclosed by the invention, the formula VI is prepared by reacting the formula V with bromoethyl ethyl ether, and a phase transfer catalyst tetrabutylammonium iodide is added, so that the reaction time is greatly shortened. the product of the formula VI is subjected to acid hydrolysis to obtain a compound II. The method is a good method for synthesizing the compound II, is mild in reaction condition, simple to operate and convenient to industrialize, and conforms to the development direction of green chemistry.

Bilastine preparation method

The invention discloses a Bilastine preparation method. The Bilastine preparation method includes that 2-nitroaniline which is low in price and easy to obtain is taken as a raw material which is subjected to reduction-n-cyclohexylmaleimide reaction, alkyl

NOVEL PROCESS FOR THE PREPARATION OF 2-[4-(2-{4-[1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL]-1-PIPERIDINYL}ETHYL) PHENYL]-2-METHYLPROPANOIC ACID

The present invention relates to novel process for the preparation of 2-[4-(2-{4-[l-(2- ethoxyethyl)-lH-benzimidazol-2-yl]-l-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid represented by the following structural formula- 1. Formula- 1 The present invention also provides novel intermediate compounds useful for the preparation of compound of formula- 1.