1181267-38-8

Basic information

• Product Name: 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester
• Synonyms: 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester
• CAS NO: 1181267-38-8
• Molecular Weight: 477.647
• Mol File: 1181267-38-8.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester(1181267-38-8)
• EPA Substance Registry System: 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester(1181267-38-8)

Safety Data

• Hazardous Substances Data: 1181267-38-8(Hazardous Substances Data)

Usage

Molecular structure

Complex

Functional groups

Benzimidazole group, piperidine group, ethoxyethyl group, acetic acid methyl ester group

Pharmaceutical properties

Likely due to benzimidazole group (anti-parasitic, anti-ulcer properties) and piperidine group (analgesic, anesthetic effects)

Potential therapeutic applications

May have therapeutic properties, further study and testing needed

Upstream product

• 98139-68-5 2-Ethoxyethyl methanesulphonate 
• 1181267-37-7 2-(4-{2-[4-(1H-benzoimidazol-2-yl)-piperidin-1-yl]-ethyl}phenyl)-2-methyl-propionic acid methyl ester 
• 953071-73-3 tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate 
• 1000536-33-3 2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid methyl ester 
• 1181267-32-2 methyl 2-methyl-2-(4-(2-(methylsulfonyloxy)ethyl)phenyl)propanoate 
• 110963-63-8 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole 
• 1181267-36-6 tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate 
• 1298022-54-4 methyl 2-methyl-2-(4-vinylphenyl)propanoate 
• 38385-95-4 2-(4-piperidinyl)-1H-benzimidazole 
• 154825-97-5 methyl 2-(4-bromophenyl)-2,2-dimethylacetate 
• 114369-15-2 2-(4-bromophenyl)ethyl methanesulfonate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 95893-88-2 N-(β-ethoxyethyl)-o-nitroaniline 
• 95893-89-3 N-(β-ethoxyethyl)-o-phenylenediamine 

Downstream Products

• 202189-78-4 Bilastine 

Relevant articles and documents

Preparation method of bilastine key intermediate

The invention belongs to the technical field of drug synthesis, and relates to 2 - (4 - (2 - (4 -ethoxyethyl) 1 - benzo [2 -] imidazol - 1H - yl) piperi d-ethyl) phenyl) -2 -methylpropionate (-1 -), and a -2 - complex and II acid are used as a catalyst to condensation the enolate anion with the compound (16 15) to form a target product II Ni Lewis. The invention aims to provide a short synthetic route. The provided route raw material condition is mild, the yield is high, the tedious building quaternary carbon atom method reported in the traditional process is avoided, and the method is suitable for industrial production.

Preparation method of bilastine

The invention provides a preparation method of bilastine. Specifically the method comprises the following steps: oxidizing 4-hydroxyethyl phenyl methyl tert-butyrate to obtain 4-acetaldehyde phenyl methyl tert-butyrate, and carrying out a reductive aminat

A new and competitive synthetic approach for an antihistamine agent, bilastine

Efforts towards the novel synthesis of second generation non-sedating antihistamine drug, Bilastine was described in this manuscript. This competitive synthetic approach involves the convergent synthesis of Bilastine via simple Friedel-Crafts acylation as an alternate for earlier reported Stille and Suzuki couplings. The selectivity in Friedel-Crafts acylation reaction with chloro acetyl chloride on different substituted arenes was studied and employed the best conditions for the synthesis of Bilastine. Further synthetic approach involves the deoxygenation of aryl ketone to corresponding alkane in single step and finally provides Bilastine with 39% of improved overall yields, utilizing simple and cost-effective reagents, suitable for kilogram scale synthesis.