95893-89-3

Basic information

• Product Name: N-(2-ETHOXY-ETHYL)-BENZENE-1,2-DIAMINE
• Synonyms: N-(2-ETHOXY-ETHYL)-BENZENE-1,2-DIAMINE;1-N-(2-ETHOXYETHYL)BENZENE-1,2-DIAMINE;N1-(2-Ethoxyethyl)benzene-1,2-diaMine
• CAS NO: 95893-89-3
• Molecular Formula: C₁₀H₁₆N₂O
• Molecular Weight: 0
• Mol File: 95893-89-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(2-ETHOXY-ETHYL)-BENZENE-1,2-DIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-ETHOXY-ETHYL)-BENZENE-1,2-DIAMINE(95893-89-3)
• EPA Substance Registry System: N-(2-ETHOXY-ETHYL)-BENZENE-1,2-DIAMINE(95893-89-3)

Safety Data

• Hazardous Substances Data: 95893-89-3(Hazardous Substances Data)

Usage

General Description

N-(2-ethoxy-ethyl)-benzene-1,2-diamine is a chemical compound that belongs to the class of organic amines. It is commonly used as an intermediate in the production of various industrial chemicals and pharmaceuticals. N-(2-ETHOXY-ETHYL)-BENZENE-1,2-DIAMINE is a derivative of benzene-1,2-diamine and contains an ethoxyethyl group attached to one of the amine nitrogen atoms. It has a wide range of applications, including as a catalyst in chemical reactions, as a building block in the synthesis of polymers and pharmaceuticals, and as an additive in various industrial processes. Due to its versatile properties, N-(2-ethoxy-ethyl)-benzene-1,2-diamine is a valuable chemical compound in the industrial and pharmaceutical sectors.

Upstream product

• 95893-88-2 N-(β-ethoxyethyl)-o-nitroaniline 
• 4926-55-0 2-[(2-nitrophenyl)amino]ethanol 
• 88-73-3 2-Chloronitrobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 95-54-5 1,2-diamino-benzene 
• 146651-75-4 tert–butyl (2–aminophenyl)carbamate 

Downstream Products

• 110963-63-8 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole 
• 101953-61-1 N-(2-ethoxyethyl)-2-benzimidazolone 
• 87233-54-3 1-(2-ethoxyethyl)-2-chloro-1H-benzimidazole 
• 101954-15-8 1-(2-Ethoxy-ethyl)-2-(4-phenyl-piperazin-1-yl)-1H-benzoimidazole 
• 101954-30-7 2-(4-Benzyl-[1,4]diazepan-1-yl)-1-(2-ethoxy-ethyl)-1H-benzoimidazole 
• 87233-79-2 2-(4-benzyl-1-piperazinyl)-1-(2-ethoxyethyl)benzimidazole 
• 101954-16-9 1-(2-Ethoxy-ethyl)-2-(4-phenethyl-piperazin-1-yl)-1H-benzoimidazole 
• 101954-18-1 2-(4-Benzhydryl-piperazin-1-yl)-1-(2-ethoxy-ethyl)-1H-benzoimidazole 
• 1181267-38-8 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester 
• 1567835-77-1 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester hydrochloride 
• 202189-78-4 Bilastine 
• 1567835-74-8 2-(1-(4-bromophenethyl)piperidin-4-yl)-1-(2-ethoxyethyl)-1H-benzo[d]imidazole 
• 1567835-76-0 1-(4-bromophenethyl)-N-(2-((2-ethoxyethyl)amino)phenyl)piperidine-4-carboxamide 

Relevant articles and documents

Cell-Based Drug Discovery: Identification and Optimization of Small Molecules that Reduce c-MYC Protein Levels in Cells

Elevated expression of the c-MYC oncogene is one of the most common abnormalities in human cancers. Unfortunately, efforts to identify pharmacological inhibitors that directly target MYC have not yet yielded a drug-like molecule due to the lack of any known small molecule binding pocket in the protein, which could be exploited to disrupt MYC function. We have recently described a strategy to target MYC indirectly, where a screening effort designed to identify compounds that can rapidly decrease endogenous c-MYC protein levels in a MYC-amplified cell line led to the discovery of a compound series that phenocopies c-MYC knockdown by siRNA. Herein, we describe our medicinal chemistry program that led to the discovery of potent, orally bioavailable c-MYC-reducing compounds. The development of a minimum pharmacophore model based on empirical structure activity relationship as well as the property-based approach used to modulate pharmacokinetics properties will be highlighted.

Emedastine hydrochloride intermediate compound and preparation method thereof

The invention provides an antihistamine medicine emedastine hydrochloride intermediate and a preparation method thereof, and is used for solving the problems of many reaction steps, operation complexity and high production cost in the preparation process

Synthesis and antihistaminic H1 activity of 1,2,5(6)-trisubstituted benzimidazoles

A number of benzimidazoles, having several substituents on the azole and benzene nuclei and C-2 (methylamino, ethylenediamine, morpholine, piperazine and piperidine) were prepared. Regioselective synthesis was designed for the N1-alkyl substituted benzimidazoles (14-15). X-Ray structure analysis of (14) was also revealed. Compounds were evaluated for their in vitro H1- antihistaminic activity in the isolated guinea-pig ileum method. The compound (11) exhibits best activity.