2030-53-7

Basic information

• Product Name: [7aS,(+)]-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline
• Synonyms: (+)-Aporrheine;(+)-Isoremerine;(6aS)-1,2-(Methylenebisoxy)-6-methyl-5,6,6aα,7-tetrahydro-4H-dibenzo[de,g]quinoline;[7aS,(+)]-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline;Aporrheine;Isoremerine;Aporeine;Aporheine
• CAS NO: 2030-53-7
• Molecular Formula: C₁₈H₁₇NO₂
• Molecular Weight: 279.3331
• Mol File: 2030-53-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 102°
• Boiling Point: 424°Cat760mmHg
• Flash Point: 162.4°C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 2.13E-07mmHg at 25°C
• Refractive Index: 1.65
• PKA: 6.1(at 25℃)
• CAS DataBase Reference: [7aS,(+)]-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: [7aS,(+)]-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline(2030-53-7)
• EPA Substance Registry System: [7aS,(+)]-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline(2030-53-7)

Safety Data

• Hazardous Substances Data: 2030-53-7(Hazardous Substances Data)

Usage

General Description

"[7aS,(+)]-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline" is a chemical compound with a complex and specific structure. It belongs to the class of benzodioxole quinoline compounds and has a tetrahydro and methyl group attached to the 7th and 7a carbon atoms. [7aS,(+)]-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline's chemical structure suggests potential pharmacological activity, likely due to its interaction with biological systems. Further research and studies may provide valuable insights into the potential uses and effects of this chemical.

InChI:InChI=1/C18H17NO2/c1-19-7-6-12-9-15-18(21-10-20-15)17-13-5-3-2-4-11(13)8-14(19)16(12)17/h2-5,9,14H,6-8,10H2,1H3/t14-/m0/s1

Upstream product

• 2030-53-7 (+/-)-roemerine 
• 71524-02-2 (S)-7-methyl-11-(1-phenyl-1H-tetrazol-5-yloxy)-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline 
• 1093-07-8 (-)-mecambrine 
• 3466-56-6 (+)-mecambroline 
• 65981-49-9 (S)-11-methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline 
• 87201-31-8 1-(2'-bromobenzyl)-3,4-dihydro-6,7-methylenedioxyisoquinoline 
• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 87201-30-7 N-<-2-(3,4-methylenedioxyphenyl)ethyl>-2'-bromophenylacetamide 

Downstream Products

• 548-08-3 (+)-roemerine 
• 548-08-3 roemerine 
• 36285-03-7 dehydroroemerine 
• 475-75-2 liriodenine 

Relevant articles and documents

Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and α1 receptor antagonists

In this study, the (S)-enantiomers of the aporphine alkaloids, nuciferine and roemerine, were prepared via a synthetic route involving catalytic asymmetric hydrogenation and both stereoisomers were evaluated in vitro for functional activity at human 5-HT2 and adrenergic α1 receptor subtypes using a transforming growth factor-α shedding assay. Both enantiomers of each of the compounds were found to act as antagonists at 5-HT2 and α1 receptors. (R)-roemerine was the most potent compound at 5-HT2A and 5-HT2C receptors (pKb = 7.8-7.9) with good selectivity compared to (S)-roemerine at these two receptors and compared to its activity at 5-HT2B, α1A, α1B and α1D receptors.