20349-66-0

Basic information

• Product Name: (4‐(methyl(phenyl)amino)phenyl)(phenyl)methanone
• Synonyms: (4‐(methyl(phenyl)amino)phenyl)(phenyl)methanone
• CAS NO: 20349-66-0
• Molecular Weight: 287.361
• Mol File: 20349-66-0.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: (4‐(methyl(phenyl)amino)phenyl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4‐(methyl(phenyl)amino)phenyl)(phenyl)methanone(20349-66-0)
• EPA Substance Registry System: (4‐(methyl(phenyl)amino)phenyl)(phenyl)methanone(20349-66-0)

Safety Data

• Hazardous Substances Data: 20349-66-0(Hazardous Substances Data)

Upstream product

• 611-94-9 4-Methoxybenzophenone 
• 100-61-8 N-methylaniline 
• 134-85-0 4-chlorobenzophenone 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 93-98-1 N-phenyl benzoyl amide 
• 552-82-9 benzhydrylidene(methyl)amine 

Downstream Products

• 19264-66-5 9H-carbazole-3-yl(phenyl)methanone 
• 111283-34-2 3-Benzoyl-9-methylcarbazol 

Relevant articles and documents

Palladium-catalyzed c(sp2)-n bond cross-coupling with triaryl phosphates

The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(-cinnamyl)Cl]2 enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.

Organic Superbase t-Bu-P4 Catalyzes Amination of Methoxy(hetero)arenes

We report that the organic superbase t-Bu-P4 efficiently catalyzes the amination of methoxy(hetero)arenes with amine nucleophiles such as aniline, indoline, and aminopyridine derivatives. This catalytic reaction is effective for the transformation of elec

NIXANTPHOS: A highly active ligand for palladium catalyzed Buchwald-Hartwig amination of unactivated aryl chlorides

Xantphos is one of the two most common ligands used in palladium catalyzed Buchwald-Hartwig amination reactions, because of its broad scope and high probability of success. It does not, however, work well with unactivated aryl chlorides. Herein NIXANTPHOS is compared to Xantphos and an array of mono- and bidentate phosphines. NIXANTPHOS outperforms Xantphos and all other bidentate ligands examined. Under the optimal reaction conditions, unactivated aryl chlorides afford the expected products in good to excellent yield with as low as 0.05 mol% (500 ppm) palladium loading.