20529-23-1

Basic information

• Product Name: 1-(3-AMinopropyl)-4-(2-Methoxyphenyl)piperazine 97%
• Synonyms: 1-(3-AMinopropyl)-4-(2-Methoxyphenyl)piperazine 97%;1-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine;3-[4-(2-Methoxyphenyl)-1-piperazinyl]propylamine
• CAS NO: 20529-23-1
• Molecular Formula: C₁₄H₂₃N₃O
• Molecular Weight: 249.35192
• Mol File: 20529-23-1.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 393.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.063±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.39±0.10(Predicted)
• BRN: 751376
• CAS DataBase Reference: 1-(3-AMinopropyl)-4-(2-Methoxyphenyl)piperazine 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-AMinopropyl)-4-(2-Methoxyphenyl)piperazine 97%(20529-23-1)
• EPA Substance Registry System: 1-(3-AMinopropyl)-4-(2-Methoxyphenyl)piperazine 97%(20529-23-1)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2735PSN1 8 / PGII
• WGK Germany: 3
• Hazardous Substances Data: 20529-23-1(Hazardous Substances Data)

Usage

Description

1-(3-Aminopropyl)-4-(2-Methoxyphenyl)piperazine 97% is a piperazine derivative, a chemical compound with a six-membered heterocyclic ring containing two nitrogen atoms. It is widely used in the pharmaceutical and research industries due to its psychoactive and potential therapeutic properties. The 97% purity of this compound ensures a high level of quality and consistency, making it suitable for various applications in medicine and research. However, it is crucial to handle this compound with care and follow strict safety protocols due to its psychoactive nature.

Uses

Used in Pharmaceutical Industry:
1-(3-Aminopropyl)-4-(2-Methoxyphenyl)piperazine 97% is used as an active pharmaceutical ingredient for the development of new psychoactive drugs. Its psychoactive properties make it a valuable compound in creating medications that target the central nervous system.
Used in Research Applications:
In the research industry, 1-(3-Aminopropyl)-4-(2-Methoxyphenyl)piperazine 97% is used as a research chemical to study its psychoactive and potential therapeutic effects. This helps scientists and researchers to better understand its mechanisms of action and explore its potential uses in various medical applications.
Used in Drug Development:
1-(3-Aminopropyl)-4-(2-Methoxyphenyl)piperazine 97% is used as a key component in the development of new drugs targeting specific medical conditions. Its psychoactive properties and potential therapeutic effects make it a promising candidate for the creation of innovative medications.
Used in Quality Control and Standardization:
The 97% purity of 1-(3-Aminopropyl)-4-(2-Methoxyphenyl)piperazine ensures a high level of quality and consistency, making it suitable for use in quality control and standardization processes within the pharmaceutical and research industries. This helps to maintain the integrity and effectiveness of the final products.

Upstream product

• 21103-25-3 3-[4-(2-methoxyphenyl)-piperazin-1-yl]-propionitrile 
• 34661-75-1 urapidil 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 102391-85-5 2‐{3‐[4‐(2‐methoxyphenyl)piperazin‐1‐yl]propyll}isoindoline‐1,3‐dione 
• 5464-78-8 1-(2-methoxyphenyl)piperazine hydrochloride 
• 21279-77-6 1-(2-methoxyphenyl)-4-(3-chloropropyl)piperazine 
• 90-04-0 2-methoxy-phenylamine 
• 79-06-1 2-propenamide 
• 178672-14-5 4-(2-methoxyphenyl)-1-piperazinepropanamide 
• 1085928-20-6 tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate 
• 178672-11-2 benzyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate 

Downstream Products

• 129011-03-6 2-Methoxy-N-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-5-sulfamoyl-benzamide 
• 188660-91-5 2-Amino-N-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-acetamide 
• 723731-91-7 2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide 

Relevant articles and documents

Synthesis, in silico, and in vitro studies of novel dopamine D2 and D3 receptor ligands

Dopamine is an important neurotransmitter in the human brain and its altered concentrations can lead to various neurological diseases. We studied the binding of novel compounds at the dopamine D2 (D2R) and D3 (D3/sub

Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase

We recently reported molecules designed according to the multitarget-directed ligand paradigm to exert combined activity at human fatty acid amide hydrolase (FAAH) and dopamine receptor subtype D3 (D3R). Both targets are relevant for tackling several types of addiction (most notably nicotine addiction) and other compulsive behaviors. Here, we report an SAR exploration of a series of biphenyl-N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl]carbamates, a novel class of molecules that had shown promising activities at the FAAH-D3R target combination in preliminary studies. We have rationalized the structural features conducive to activities at the main targets and investigated activities at two off-targets: dopamine receptor subtype D2 and endocannabinoid receptor CB1. To understand the unexpected affinity for the CB1 receptor, we devised a 3D-QSAR model, which we then prospectively validated. Compound 33 was selected for PK studies because it displayed balanced affinities for the main targets and clear selectivity over the two off-targets. 33 has good stability and oral bioavailability and can cross the blood-brain barrier.

Synthesis and evaluation of antiproliferative activity of novel quinazolin-4(3H)-one derivatives

Two series of novel quinazolin-4(3H)-one derivatives (10a–g and 11a–g) have been synthesized and evaluated for their in vitro antiproliferative activity against human HeLa, MIAPACA, MDA-MB-231, and IMR-31 cancer cell lines. The synthesized compounds were characterized by spectral (Fourier transform infrared, 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, high-resolution mass spectra) methods. Among them, compounds 11e and 11g exhibited potent in vitro antiproliferative activity with GI50 values 0.02, less than 0.01 μM against MIAPACA human cancer cell line. Significantly, compounds 10a, 10b, 10c, 10g, 11b, 11c, 11d, 11e, 11f showed activity with GI50 values ranging from 0.1 to 0.87 μM against human cancer cell lines MIAPACA, MDA-MB-231, and IMR-31. We have explored the probable binding mode and key active site interactions in HDAC8 and EHMT2 proteins. The docking results are complementary to the experimental results.