1085928-20-6

Basic information

• Product Name: tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate
• Synonyms: tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate
• CAS NO: 1085928-20-6
• Molecular Weight: 349.473
• Mol File: 1085928-20-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate(1085928-20-6)
• EPA Substance Registry System: tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate(1085928-20-6)

Safety Data

• Hazardous Substances Data: 1085928-20-6(Hazardous Substances Data)

Upstream product

• 5464-78-8 1-(2-methoxyphenyl)piperazine hydrochloride 
• 80909-96-2 O-tosyl-3-tert-butoxycarbonylamino-1-propanol 
• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 83948-53-2 3-bromopropylamine tert-butylcarbamate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1610591-95-1 3-amino-5-chloro-6-methoxy-N-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-4-methylthieno[2,3-b]pyridine-2-carboxamide 
• 20529-23-1 3-(4-(2-methoxyphenyl)piperazin-1-yl)propylamine 

Relevant articles and documents

Novel naftopidil-related derivatives and their biological effects as alpha1-adrenoceptors antagonists and antiproliferative agents

Eleven novel naftopidil-related compounds that contain amide and indole groups were designed and synthesized. The biological effects of these compounds on three ±1-adrenoceptor subtypes and cancerous human prostate cell lines (PC-3, DU-145, and LNCaP) were determined. Compounds 2, 3, 5, 11, and 12 exhibited an 1-adrenoceptor antagonistic activity, whereas compounds 9, 10, and 12 displayed moderate antiproliferative activities. Compound 3 exhibited a significant ±1D/1A blocking activity in isolated rat tissues (97.7-and 64.6-fold selective for ±1D and ±1A compared with 1B) but not a relevant cytotoxic activity. Compound 12 demonstrated a potent and selective 1D/1A antagonistic activity (47.9-and 19.1-fold for 1D and ±1A compared with ±1B) and a potent antiproliferative activity in PC-3 cells (IC50 = 15.70 μM). Further testing confirmed that compound 12 inhibited the growth of PC-3 cells by inducing apoptosis and G0/G1 cell cycle arrest, which was mediated by ±1-adrenoceptor. Therefore, compound 12 is a potential multipotent agent that can act as an effective ±1-adrenoceptor subtype antagonist for treating benign prostatic hyperplasia and a preventive medication against human prostate cancer.

COMPSITIONS, SYNTHESIS, AND METHODS OF USING QUINOLINE BASED ATYPICAL ANTIPSYCHOTIC AGENTS

The present invention provides novel quinolinone derivatives which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder, and depression.