206268-34-0Relevant articles and documents
Synthesis of perhydrodiazepinones as new putative peptidomimetics
Nouvet, Andre,Binard, Marc,Lamaty, Frederic,Martinez, Jean,Lazaro, Rene
, p. 4685 - 4698 (2007/10/03)
New functionalized 7-membered azaheterocycles (perhydrodiazepinones) have been designed as new scaffolds supposed to mimick peptide γ-turns constrained by an ethylene bridge. They were synthesized by either lactam cyclisation on an aminoacid compound outcoming from a glutamic acid derivative starting material or through an intramolecular Mitsunobu reaction on diaminoalcohol linear precursors. Furthermore, as a new strategy useful for combinatorial chemistry, the second synthesis has been investigated on a soluble polymer support (PEG).