20887-04-1

Basic information

• Product Name: Benzamide, 2-amino-4-chloro-N-phenyl-
• CAS NO: 20887-04-1
• Molecular Formula: C13H11ClN2O
• Molecular Weight: 246.696
• Mol File: 20887-04-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzamide, 2-amino-4-chloro-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-amino-4-chloro-N-phenyl-(20887-04-1)
• EPA Substance Registry System: Benzamide, 2-amino-4-chloro-N-phenyl-(20887-04-1)

Safety Data

• Hazardous Substances Data: 20887-04-1(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 5900-59-4 2-amino-4-chlorobenzamide 
• 14313-60-1 6-chlorobenzo[c]isoxazole? 
• 62-53-3 aniline 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 41995-04-4 4-chloro-2-nitro-benzoyl chloride 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 349406-24-2 2-nitro-4-chlorobenzanilide 
• 40928-13-0 4-chloroisatoic anhydride 

Downstream Products

• 7012-90-0 7-chloro-2-methyl-3-phenyl-3H-quinazolin-4-one 
• 57623-85-5 4-Chloro-N-phenyl-2-phenylamino-benzamide 
• 1451261-62-3 2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chloro-N-phenylbenzamide 
• 1083418-35-2 5-(4-chloro-phenyl)-2-trifluoromethyl-furan-3-carboxylic acid (5-chloro-2-phenyl-carbamoyl-phenyl)-amide 
• 20887-05-2 5-Chlor-2-anilinomethylanilin 

Relevant articles and documents

Visible-light induced copper(i)-catalyzed oxidative cyclization of: O -aminobenzamides with methanol and ethanol via HAT

The use of the in situ generated ligand-copper superoxo complex absorbing light energy to activate the alpha C(sp3)-H of MeOH and EtOH via the hydrogen atom transfer (HAT) process for the synthesis of quinazolinones by oxidative cyclization of alcohols with o-aminobenzamide has been investigated. The synthetic utility of this protocol offers an efficient synthesis of a quinazolinone intermediate for erlotinb (anti-cancer agent) and 30 examples were reported.

One-Pot, Multistep Reactions for the Modular Synthesis of N, N′-Diarylindazol-3-ones

The pot-economic synthesis of N,N′-diarylindazol-3-ones has been developed using readily available isatoic anhydrides, aryl amines, and aryl boronic acids. A Cu-catalyzed oxidative C-N cross-coupling and dehydrogenative N-N formation sequence under an air atmosphere affords indazol-3-one derivatives in good to excellent yields. Such process merges well with the preceding decarboxylative amination reaction, resulting in a more modular and straightforward approach.

Sustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions

Alcohols and ethers were identified as sustainable methine sources for synthesizing quinazolinone and benzimidazole derivatives using a combination of TsOH·H2O/O2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone (2e′), 2f′ (a common precursor of rutaecarpine and (±) evodiamine), and dimedazole (6d). Notable features of this method include its low toxicity, use of commercial feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials.