21288-34-6

Basic information

• Product Name: Benzeneacetonitrile,3-benzoyl-
• Synonyms: Acetonitrile,(m-benzoylphenyl)- (8CI); (3-Benzoylphenyl)acetonitrile;3-(Cyanomethyl)benzophenone; 3-Benzoylbenzeneacetonitrile; RU 5029;m-Benzoylphenylacetonitrile
• CAS NO: 21288-34-6
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.2539
• EINECS: 244-315-3
• Product Categories: Aromatics Compounds;Aromatics;Intermediates
• Mol File: 21288-34-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 406.2°Cat760mmHg
• Flash Point: 199.4°C
• Appearance: /
• Density: 1.141g/cm³
• Vapor Pressure: 8.3E-07mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• CAS DataBase Reference: Benzeneacetonitrile,3-benzoyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile,3-benzoyl-(21288-34-6)
• EPA Substance Registry System: Benzeneacetonitrile,3-benzoyl-(21288-34-6)

Safety Data

• Hazardous Substances Data: 21288-34-6(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Oil

Uses

Ketoprofen intermediate

InChI:InChI=1/C15H11NO/c16-10-9-12-5-4-8-14(11-12)15(17)13-6-2-1-3-7-13/h1-8,11H,9H2

Upstream product

• 22071-24-5 3-benzoylbenzyl bromide 
• 143-33-9 sodium cyanide 
• 151-50-8 potassium cyanide 
• 1711-06-4 3-Methylbenzoyl chloride 
• 71-43-2 benzene 
• 13435-20-6 tetraethylammoniumcyanide 
• 643-65-2 3-methyl benzophenone 
• 106-93-4 ethylene dibromide 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 22071-22-3 2-(3-benzoylphenyl)acetic acid 
• 80472-44-2 (E)-2-(3-Benzoyl-phenyl)-3-phenyl-acrylonitrile 
• 22071-15-4 ketoprofen 
• 42872-30-0 alpha-(m-benzoylphenyl)propionitrile 
• 691404-94-1 2-(3-benzoyl-phenyl)-malononitrile 
• 691404-97-4 2-(3-benzyl-phenyl)-malononitrile 
• 691405-00-2 2-[3-(hydroxy-phenyl-methyl)-phenyl]-malononitrile 
• 319482-67-2 3-(β-hydroxyethyl)benzophenone 
• 60695-25-2 2,6-Dimethyl-1-{2-[3-(α-hydroxybenzyl)phenyl]ethyl}-piperidine 
• 60695-78-5 {3-[2-(2-Cyclohexylmethyl-piperidin-1-yl)-ethyl]-phenyl}-phenyl-methanone 
• 60695-24-1 2-cyclohexylmethyl-1-{2-[3-(α-hydroxybenzyl)phenyl]ethyl}piperidine 
• 41652-38-4 (3-benzoylphenyl)acetyl chloride 
• 60695-29-6 N-[(3-benzoylphenyl)acetyl]-N-(3-dimethylaminopropyl)amine 
• 81597-82-2 4-<2-(3-benzoylphenyl)-1-oxoethyl>morpholine 

Relevant articles and documents

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors

Employing phenylmalonitrile dianion chemistry, a large number of analogues of MEK inhibitor lead SH053 (IC50=140 nM) were rapidly synthesized leading to single digit nM inhibitors, displaying submicromolar AP-1 transcription inhibition in COS-7 cells. Compound 41, exhibiting a MEK IC 50=12 nM showed ip activity in a TPA-induced ear edema model with an ED50=5 mg/kg.

Efficient photodecarboxylation of aroyl-substituted phenylacetic acids in aqueous solution: A general photochemical reaction

Photolysis (254-350 nm) of a variety of aroyl-substituted phenylacetic acids and p-acetylphenylacetic acid in aqueous solution at pH > pK(a) resulted in efficient photodecarboxylation (Φ = 0.2-0.7), to give in most cases a single product arising via the corresponding arylmethyl carbanion, indicating that photodecarboxylation is an efficient and general reaction for these types of compounds.