218608-99-2 Usage
General Description
BOC-(S)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID is a complex chemical compound that falls under the category of fluorinated building blocks. As a derivative of butyric acid with a molecular weight of 277.27, this compound features numerous elements, including carbon, hydrogen, nitrogen, oxygen, and fluorine. Its application is mainly in the field of chemistry and biochemistry for chemical and biological experiments, more specifically in pharmaceutical development due to its potential in synthesizing complex molecules and drugs. The exact biological activity and mechanism of action of this compound are potentially vast and depend on the context of its use. Hence, it is essential to operate under careful handling and safety guidelines while working with it.
Check Digit Verification of cas no
The CAS Registry Mumber 218608-99-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,8,6,0 and 8 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 218608-99:
(8*2)+(7*1)+(6*8)+(5*6)+(4*0)+(3*8)+(2*9)+(1*9)=152
152 % 10 = 2
So 218608-99-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H20FNO4/c1-15(2,3)21-14(20)17-11(9-13(18)19)8-10-6-4-5-7-12(10)16/h4-7,11H,8-9H2,1-3H3,(H,17,20)(H,18,19)/t11-/m0/s1
218608-99-2Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
