22421-36-9

Basic information

• Product Name: α-benzyl-α-methyl-γ-butyrolactone
• Synonyms: α-benzyl-α-methyl-γ-butyrolactone
• CAS NO: 22421-36-9
• Molecular Weight: 190.242
• Mol File: 22421-36-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: α-benzyl-α-methyl-γ-butyrolactone(CAS DataBase Reference)
• NIST Chemistry Reference: α-benzyl-α-methyl-γ-butyrolactone(22421-36-9)
• EPA Substance Registry System: α-benzyl-α-methyl-γ-butyrolactone(22421-36-9)

Safety Data

• Hazardous Substances Data: 22421-36-9(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 33693-67-3 α-bromo-α-methyl-γ-butyrolactone 
• 62673-31-8 benzyl(bromo)zinc 

Downstream Products

• 719282-77-6 S-(+)-α-benzyl-α-methyl-γ-butyrolactone 
• 80245-81-4 3-Benzyl-3,4-dimethyl-1,4-pentandiol 

Relevant articles and documents

Formation of quaternary carbons through cobalt-catalyzed C(sp3)-C(sp3) Negishi cross-coupling

Formation of all-carbon-substituted quaternary carbons is a key challenge in organic and medicinal chemistry. We report a cobalt-catalyzed C(sp3)-C(sp3) cross-coupling that allows for the introduction of benzyl, heteroarylmethylzinc and allyl groups to halo-carbonyl substrates. The cross-coupling reaction is selective for C(sp3)-over C(sp2)-halides, in contrast to most used catalytic metals, and allows access to novel scaffolds of pharmaceutical interest. NMR mechanistic studies suggest the presence of Co(0) complexes as catalytic species. This journal is