22677-21-0 Usage
Description
2-Pyrrolidinone,4-hydroxy-, (4R)-, also known as (R)-(+)-4-Hydroxy-2-pyrrolidinone, is a white to light yellow crystalline powder. It is an enantiomeric intermediate with significant applications in the pharmaceutical industry due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
2-Pyrrolidinone,4-hydroxy-, (4R)is used as an intermediate in the preparation of Oxiracetam, a cognitive enhancer and nootropic drug. Its enantiomeric nature allows for the development of single isomeric drugs with improved efficacy and reduced side effects.
Used in Antitumor Applications:
2-Pyrrolidinone,4-hydroxy-, (4R)is used as an enantiomeric intermediate for the development of antitumor drugs. Its unique properties enable the creation of targeted therapies with enhanced effectiveness against various types of cancer.
Used in Anesthetic Applications:
In the field of anesthesiology, 2-Pyrrolidinone,4-hydroxy-, (4R)is utilized as an intermediate for the synthesis of chiral anesthetic agents. These agents provide improved selectivity and reduced side effects compared to their racemic counterparts.
Used in Antipasmodic Applications:
2-Pyrrolidinone,4-hydroxy-, (4R)is employed as an enantiomeric intermediate in the development of antipasmodic drugs, which are used to treat muscle spasms and related conditions. Its enantiomeric nature allows for the creation of more effective and safer medications.
Used in Anti-inflammatory Applications:
In the realm of anti-inflammatory drugs, 2-Pyrrolidinone,4-hydroxy-, (4R)serves as an intermediate for the synthesis of chiral anti-inflammatory agents. These drugs exhibit better efficacy and fewer side effects due to their targeted action.
Used in Anti-HIV Applications:
2-Pyrrolidinone,4-hydroxy-, (4R)is also used as an enantiomeric intermediate in the development of anti-HIV drugs. Its unique properties enable the creation of more potent and selective medications to combat the virus.
Check Digit Verification of cas no
The CAS Registry Mumber 22677-21-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,6,7 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 22677-21:
(7*2)+(6*2)+(5*6)+(4*7)+(3*7)+(2*2)+(1*1)=110
110 % 10 = 0
So 22677-21-0 is a valid CAS Registry Number.
InChI:InChI=1/C4H7NO2/c6-3-1-4(7)5-2-3/h3,6H,1-2H2,(H,5,7)/t3-/m1/s1
22677-21-0Relevant articles and documents
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Balenovic et al.
, p. 1589,1591 (1954)
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An efficient synthesis of (R)-GABOB and of (±)-GABOB
Sabin, Engin,Kishali, Nurhan,Kelebekli, Lauf,Mete, Ebru,Secen, Hasan,Altundas, Ramazan,Kara, Yunus
, p. 509 - 513 (2007)
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PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS
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, (2010/03/02)
The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.
An efficient scalable process for the synthesis of N-Boc-2-tert-butyldimethylsiloxypyrrole
Tian, Zhenping,Rasmussen, Michael,Wittenberger, Steven J.
, p. 416 - 418 (2013/09/06)
A safe, reliable and scalable process for the preparation of N-Boc-2-tert-butyldimethylsiloxy-pyrrole (TBSOP) is described. In a three-step, one-pot sequence (±)-4-amino-3-hydroxybutyric acid was converted to N-Boc-4-hydroxy-2-pyrrolidinone. This stable crystalline product was isolated by filtration directly from the reaction mixture. Dehydration followed by enolization and silylation produced the target compound without the need for chromatographic purification. The process was demonstrated in the pilot plant to make multikilogram quantities of material in 85% overall yield.