227617-17-6

Basic information

• Product Name: 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 4-butoxy-1-[(4-methoxyphenyl)methyl]-
• CAS NO: 227617-17-6
• Molecular Formula: C19H21N3O4
• Molecular Weight: 355.393
• Mol File: 227617-17-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 4-butoxy-1-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 4-butoxy-1-[(4-methoxyphenyl)methyl]-(227617-17-6)
• EPA Substance Registry System: 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 4-butoxy-1-[(4-methoxyphenyl)methyl]-(227617-17-6)

Safety Data

• Hazardous Substances Data: 227617-17-6(Hazardous Substances Data)

Upstream product

• 2372-45-4 sodium butanolate 
• 227617-16-5 ethyl 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 
• 227617-15-4 4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 3528-45-8 1-(4-methoxybenzyl)-1H-pyrazol-5-amine 

Downstream Products

• 582315-56-8 4-butoxy-1-(4-methoxy-benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethylamide 
• 227617-18-7 4-Butoxy-N-methoxy-1-[(4-methoxyphenyl)methyl]-N-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 
• 582315-72-8 BMS-265246 
• 60868-76-0 SQ-67563 

Relevant articles and documents

USE OF PYRAZOLO [3,4-b] PYRIDINE AS CYCLIN DEPENDANT KINASE INHIBITORS

Compounds of the formula and pharmaceutically acceptable salts thereof for use as inhibitors of cyclin dependent kinases, wherein: X is O, S(O)m; Y is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl; R1 is hydrogen or lower alkyl; R2 is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, -O-alkyl, -O-aryl, -NR4R5; R3 is hydrogen or lower alkyl; R4 is hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, -O-alkyl, -O-aryl; R5 is hydrogen, alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, cycloalkyl, alkylcycloalkyl, heterocycloalkyl, alkylheterocycloalkyl, -O-alkyl, -O-aryl; and m is 0, 1 or 2. The compounds of formula I are protein kinase inhibitors and are useful in the treatment and prevention of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of neurodegenerative diseases such as Alzheimer's disease, cardiovascular diseases, viral diseases and fungal diseases.

Use of pyrazolo [3,4-b] pyridine as cyclin dependent kinase inhibitors

Compounds of the formula and pharmaceutically acceptable salts thereof for use as inhibitors of cyclin dependent kinases, wherein: X is O, S(O)m; Y is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, hete